Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1
Abstract
The protein synthesis-dependent form of hippocampal long-term potentiation (late-LTP) is thought to underlie memory. Its induction requires a distinct stimulation strength, and the common opinion is that only repeated tetani result in late-LTP whereas as single tetanus only reveals a transient early-LTP. Properties of LTP induction were compared to learning processes where repetition is often the prerequisite for a long-lasting memory. However, also single events can lead to manifested memory. If LTP subserves processes of learning, similar results should be detectable for LTP. Here we show that a single tetanus is sufficient to induce late-LTP requiring dopaminergic co-transmission during induction.
Footnotes
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↵1 Corresponding author.
↵1 E-mail frey@ifn-magdeburg.de; fax 49-391-6263421.
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.816908
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- Received October 22, 2007.
- Accepted November 28, 2007.
- Copyright © 2008, Cold Spring Harbor Laboratory Press