- © 2018 by the Association of Clinical Scientists, Inc.
Circulating RBP4 Increase and Its Diagnosis of Chronic Kidney Disease
- 1Fuling Hospital of Chinese Medicine, Chongqing, China
- 2Basic Medicine Science of Jiu Jiang University, Jiujiang, Jiangxi, China
- 3The Affiliated Hospital of Jiu Jiang University, Jiujiang, Jiangxi, China
- Address correspondence to Chunhua Xun, Fuling Hospital of Chinese Medicine, Chongqing, 408000, China; phone: + 86 02361030930; fax: +86 02361030930; e mail: z6x2m{at}163.com
Abstract
Objective Sera retinol binding protein 4 (RBP4) has been associated with renal function. We determined the concentration of sera RBP4 in chronic kidney disease (CKD) and found its diagnostic value for CKD.
Materials and Methods The sera samples were collected from 51 patients with CKD and 30 healthy control. The presence of circulating RBP4 was quantified by Enzyme-linked immunosorbent assay (ELISA), cystain C (CysC), urea, creatinine (CREA), uric acid (UA), total protein (TP), albumin (ALB) and 24 hours urinary protein (PRO) were examined by automatic biochemical analyzer.
Results Levels of circulating RBP4 was significantly higher in CKD than in control (P<0.05). Serum RBP4 was positively related to serum urea, CREA and CysC (P<0.01). Receiver operating characteristic (ROC) analysis showed that the area under the curve (AUC) of RBP4 was 0.734. When the cutoff was 78.75ng/ml, the sensitivity and specificity were 52.9% and 100%, respectively.
Conclusion This is the first study to show that RBP4 could be usable for CKD diagnosis.
