NAD+ as a Signaling Molecule Modulating Metabolism

  1. J. Auwerx2
  1. 1Nestlé Institute of Health Sciences, CH-1015, Lausanne, Switzerland
  2. 2Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
  1. Correspondence: admin.auwerx{at}epfl.ch

Abstract

The ability of NAD+ to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD+ levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD+ have become highly relevant issues that we need to understand in order to elucidate how NAD+ acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.

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