The role of nitric oxide in nociception
ZD Luo, D Cizkova - Current review of pain, 2000 - Springer
Pharmacologic, electrophysiologic, and immunohistochemical studies have suggested a role
of nitric oxide (NO) in nociception processing. Recent studies have indicated that NO may …
of nitric oxide (NO) in nociception processing. Recent studies have indicated that NO may …
Calcium channel functions in pain processing
J Park, ZD Luo - Channels, 2010 - Taylor & Francis
… Z. David Luo … Perret D, Luo ZD. Targeting voltage-gated calcium channels for
neuropathic pain management. Neurotherapeutics 2009; 6:679 - 692 …
neuropathic pain management. Neurotherapeutics 2009; 6:679 - 692 …
[HTML][HTML] Targeting voltage-gated calcium channels for neuropathic pain management
D Perret, ZD Luo - Neurotherapeutics, 2009 - Elsevier
Voltage-gated calcium channels (VGCC) play obligatory roles in diverse physiological
functions. Pathological conditions leading to changes in their biophysical properties and …
functions. Pathological conditions leading to changes in their biophysical properties and …
[HTML][HTML] Gabapentin receptor α2δ-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis
Synapses are asymmetric cellular adhesions that are critical for nervous system development
and function, but the mechanisms that induce their formation are not well understood. We …
and function, but the mechanisms that induce their formation are not well understood. We …
Upregulation of dorsal root ganglion α2δ calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats
ZD Luo, SR Chaplan, ES Higuera… - Journal of …, 2001 - Soc Neuroscience
Peripheral nerve injury can lead to a persistent neuropathic pain state in which innocuous
tactile stimulation elicits pain behavior (tactile allodynia). Spinal administration of the …
tactile stimulation elicits pain behavior (tactile allodynia). Spinal administration of the …
The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal …
…, CM Conway, C Svensson, ZD Luo… - Journal of …, 2001 - Soc Neuroscience
Western blots show the constitutive expression of COX-1 and COX-2 in the rat spinal dorsal
and ventral horns and in the dorsal root ganglia. Using selective inhibitors of …
and ventral horns and in the dorsal root ganglia. Using selective inhibitors of …
Calcium channel α2δ1 subunit mediates spinal hyperexcitability in pain modulation
…, J Gross, MS Gold, AH Dickenson, G Feng, ZD Luo - Pain, 2006 - Elsevier
Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation
of voltage-gated calcium channel (VGCC) α 2 δ 1 subunit (Ca v α 2 δ 1 ) in sensory …
of voltage-gated calcium channel (VGCC) α 2 δ 1 subunit (Ca v α 2 δ 1 ) in sensory …
Spinal dorsal horn calcium channel α2δ-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia
CY Li, YH Song, ES Higuera, ZD Luo - Journal of Neuroscience, 2004 - Soc Neuroscience
Peripheral nerve injury induces upregulation of the calcium channel α 2 δ-1 structural
subunit in dorsal root ganglia (DRG) and dorsal spinal cord of spinal nerve-ligated rats with …
subunit in dorsal root ganglia (DRG) and dorsal spinal cord of spinal nerve-ligated rats with …
Selective increase of tumour necrosis factor‐alpha in injured and spared myelinated primary afferents after chronic constrictive injury of rat sciatic nerve
…, C Geis, CI Svensson, ZD Luo… - European Journal of …, 2003 - Wiley Online Library
Chronic constriction of the sciatic nerve, leading to a hyperalgesic state, results in a partial
lesion wherein some axons are injured and others remain intact. Here we sought to …
lesion wherein some axons are injured and others remain intact. Here we sought to …
Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states
…, J Zeng, K Sharp, D Kim, O Steward, ZD Luo - PAINŽ, 2011 - Elsevier
Spinal cord injury (SCI) commonly results in the development of neuropathic pain, which can
dramatically impair the quality of life for SCI patients. SCI-induced neuropathic pain can be …
dramatically impair the quality of life for SCI patients. SCI-induced neuropathic pain can be …