Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …

The neurotrophic proteins BDNF and NGF are related in their primary structures, and both
have high-and lowaffinity receptors on their responsive neurons. In this study, we investigate …

DURING the development of the vertebrate nervous system, many neurons depend for
survival on interactions with their target cells 1 . Specific proteins are thought to be released by …

BRAIN-derived neurotrophic factor (BDNF), present in minute amounts in the adult central
nervous system 1 , is a member of the nerve growth factor (NGF) (ref. 2) family, which includes …

THE survival and functional maintenance of vertebrate neurons critically depends on the
availability of specific neurotrophic factors 1–3 . So far, only two such factors, nerve growth …

We report the purification from pig brain of a factor supporting the survival of, and fibre
outgrowth from, cultured embryonic chick sensory neurons. The purified factor migrates as one …

The neurotrophins are a small group of dimeric proteins that profoundly affect the development
of the nervous system of vertebrates. Recent studies have established clear correlations …

A recurrent observation in the development of the nervous system is the generation of
neurons followed by their large scale elimination. This phenomenon, usually referred to as …

Brain-derived neurotrophic factor (BDNF) is a small, basic protein purified from the mammalian
brain that has been shown previously to support the survival of cultured spinal sensory …

THE number of neurotrophic factors found in the central nervous system is rapidly growing,
but their functions in vivo are largely unknown. In the peripheral nervous system they …