Neuropathic pain, a debilitating pain condition, is a common consequence of damage to the
nervous system. Optimal treatment of neuropathic pain is a major clinical challenge …

Chronic itch is an intractable symptom of inflammatory skin diseases, such as atopic and
contact dermatitis 1 , 2 , 3 . Recent studies have revealed neuronal pathways selective for itch 4 …

Activation of purinergic receptors in the spinal cord by extracellular ATP is essential for
neuropathic hypersensitivity after peripheral nerve injury (PNI). However, the cell type …

Astrocytes are critical regulators of CNS function and are proposed to be heterogeneous in
the developing brain and spinal cord. Here we identify a population of astrocytes located in …

Diurnal variations in pain hypersensitivity are common in chronic pain disorders, but the
underlying mechanisms are enigmatic. Here, we report that mechanical pain hypersensitivity in …

Noninvasive gene delivery to the spinal dorsal horn (SDH) remains challenging because
existing methods to directly microinject vectors require laminectomy, which leads to tissue …

Neuropathic pain is caused by peripheral nerve injury (PNI). One hallmark symptom is allodynia
(pain caused by normally innocuous stimuli), but its mechanistic underpinning remains …

Accumulating evidence indicates that peripheral nerve injury (PNI) activates spinal microglia
that are necessary for neuropathic pain. Recent studies using bone marrow (BM) chimeric …

Neuropathic pain, a highly debilitating chronic pain following nerve damage, is a reflection
of the aberrant functioning of a pathologically altered nervous system. Previous studies have …

Pain transmission and processing in the nervous system are modulated by various biologically
active substances, including lysophospholipids, through direct and indirect actions on the …