Biologic scaffolds composed of central nervous system extracellular matrix
…, CJ Medberry, JE Reing, S Tottey, Y van der Merwe… - Biomaterials, 2012 - Elsevier
Acellular biologic scaffolds are commonly used to facilitate the constructive remodeling of
three of the four traditional tissue types: connective, epithelial, and muscle tissues. However, …
three of the four traditional tissue types: connective, epithelial, and muscle tissues. However, …
[HTML][HTML] Extracellular vesicles: biomarkers, therapeutics, and vehicles in the visual system
Y van der Merwe, MB Steketee - Current Ophthalmology Reports, 2017 - Springer
Purpose We discuss recent advances in extracellular vesicle (EV) technology as biomarkers,
therapeutics, and drug delivery vehicles in the visual system with an emphasis on the retina…
therapeutics, and drug delivery vehicles in the visual system with an emphasis on the retina…
[HTML][HTML] Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function
Y van der Merwe, AE Faust, ET Sakalli, CC Westrick… - Scientific reports, 2019 - nature.com
Injury to retinal ganglion cells (RGC), central nervous system neurons that relay visual
information to the brain, often leads to RGC axon degeneration and permanently lost visual …
information to the brain, often leads to RGC axon degeneration and permanently lost visual …
Urinary bladder extracellular matrix hydrogels and matrix-bound vesicles differentially regulate central nervous system neuron viability and axon growth and …
…, A Kandakatla, Y van der Merwe… - Journal of …, 2017 - journals.sagepub.com
Central nervous system neurons often degenerate after trauma due to the inflammatory
innate immune response to injury, which can lead to neuronal cell death, scarring, and …
innate immune response to injury, which can lead to neuronal cell death, scarring, and …
[HTML][HTML] Citicoline modulates glaucomatous neurodegeneration through intraocular pressure-independent control
Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss.
Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. However, …
Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. However, …
Intracameral injection of a chemically cross-linked hydrogel to study chronic neurodegeneration in glaucoma
…, Y Yu, SH Ng, HK Mak, YWY Yip, Y van der Merwe… - Acta biomaterialia, 2019 - Elsevier
Investigation of neurodegeneration in glaucoma, a leading cause of irreversible blindness
worldwide, has been obfuscated by the lack of an efficient model that provides chronic, mild to …
worldwide, has been obfuscated by the lack of an efficient model that provides chronic, mild to …
[HTML][HTML] Age-related changes in eye, brain and visuomotor behavior in the DBA/2J mouse model of chronic glaucoma
XL Yang, Y Van Der Merwe, J Sims, C Parra, LC Ho… - Scientific reports, 2018 - nature.com
Although elevated intraocular pressure (IOP) and age are major risk factors for glaucoma,
their effects on glaucoma pathogenesis remain unclear. This study examined the onset and …
their effects on glaucoma pathogenesis remain unclear. This study examined the onset and …
Developing extracellular matrix technology to treat retinal or optic nerve injury
T Ren, Y van der Merwe, MB Steketee - ENeuro, 2015 - eneuro.org
Adult mammalian CNS neurons often degenerate after injury, leading to lost neurologic
functions. In the visual system, retinal or optic nerve injury often leads to retinal ganglion cell …
functions. In the visual system, retinal or optic nerve injury often leads to retinal ganglion cell …
Whole-globe biomechanics using high-field MRI
…, LC Ho, NJ Jan, H Tran, Y van der Merwe… - Experimental eye …, 2017 - Elsevier
The eye is a complex structure composed of several interconnected tissues acting together,
across the whole globe, to resist deformation due to intraocular pressure (IOP). However, …
across the whole globe, to resist deformation due to intraocular pressure (IOP). However, …
[HTML][HTML] Non-invasive MRI assessments of tissue microstructures and macromolecules in the eye upon biomechanical or biochemical modulation
The microstructural organization and composition of the corneoscleral shell (CSS) determine
the biomechanical behavior of the eye, and are important in diseases such as glaucoma …
the biomechanical behavior of the eye, and are important in diseases such as glaucoma …