Background Chronic pain is currently a significant health problem in the United States. A
comprehensive strategy is needed to increase prevention of chronic pain and to improve care …

The aim of this study was to use a supersaturated split-plot design to identify the significant
effects of ten ingredients, each at two levels, and two levels of screw speed on selected …

Distal symmetrical polyneuropathy is the most common form of HIV infection-associated
peripheral neuropathy and is often associated with pain. C57BL/6 (B6) mice infected with LP-…

The generalized doubly robust estimator is proposed for estimating the average treatment
effect (ATE) of multiple treatments based on the generalized propensity score (GPS). In …

In observational studies, unbalanced observed covariates between treatment groups often
cause biased inferences on the estimation of treatment effects. Recently, generalized …

Methods to construct supersaturated split-plot designs (SSSPDs) are presented. We use an
E(s 2 )-optimal supersaturated design (SSD) in the whole-plot and half fractions of Plackett–…

CD137L (4-1BBL) is a costimulatory molecule whose signaling can promote monocyte/macrophage
functions; however, CD137L-mediated microglial response and its role in …

The overlap assumption (OA) of the generalized propensity score (GPS) is often violated
when the number of treatments increases (Lin et al., 2019 ), especially when the GPS is …

Overdevelopment of visceral adipose is positively correlated with the etiology of obesity‐associated
pathologies including cardiovascular disease and insulin resistance. However, …

Overfishing and habitat loss have reduced Pseudopleuronectes americanus (Winter Flounder)
populations within the Gulf of Maine (GOM), and despite strict management regulations, …