[HTML][HTML] Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction

…, SA Rosenthal, K Liu Kot, Y Liu, WW Yen… - PLoS …, 2020 - journals.plos.org
Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased
expression of the immune gene C4 has been linked to a greater risk of developing schizophrenia…

Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice

KN Borrelli, EJ Yao, WW Yen, RA Phadke, QT Ruan… - ENeuro, 2021 - eneuro.org
The opioid epidemic led to an increase in the number of neonatal opioid withdrawal syndrome
(NOWS) cases in infants born to opioid-dependent mothers. Hallmark features of NOWS …

Highly unstable heterogeneous representations in VIP interneurons of the anterior cingulate cortex

C Johnson, LN Kretsge, WW Yen, B Sriram… - Molecular …, 2022 - nature.com
A hallmark of the anterior cingulate cortex (ACC) is its functional heterogeneity. Functional
and imaging studies revealed its importance in the encoding of anxiety-related and social …

[HTML][HTML] Dynamics and durability of HIV-1 neutralization are determined by viral replication

…, C Geldmacher, O Geisenberger, A Kroidl, W William… - Nature Medicine, 2023 - nature.com
Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent
infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet …

A pipeline using bilateral in utero electroporation to interrogate genetic influences on rodent behavior

AL Comer, B Sriram, WW Yen, A Cruz-Martín - JoVE (Journal of Visualized …, 2020 - jove.com
As genome-wide association studies shed light on the heterogeneous genetic underpinnings
of many neurological diseases, the need to study the contribution of specific genes to brain …

Distinct VIP interneurons in the cingulate cortex encode anxiogenic and social stimuli

C Johnson, LN Kretsge, WW Yen, B Sriram… - bioRxiv, 2020 - biorxiv.org
A hallmark of higher-order cortical regions is their functional heterogeneity, but it is not well
understood how these areas encode such diverse information. The anterior cingulate cortex (…

Stochastic optimization of multiple-reservoir-system operation

BPF Braga Jr, WWG Yen, L Becker… - Journal of Water …, 1991 - ascelibrary.org
A stochastic dynamic programming model for the optimization of hydropower prroduction of
a multiple storage‐reservoir system with correlated inflows has been developed. Application …

A combinatorial optimization scheme for parameter structure identification in ground water modeling

FTC Tsai, NZ Sun, WWG Yen - Groundwater, 2003 - Wiley Online Library
This research develops a methodology for parameter structure identification in ground water
modeling. For a given set of observations, parameter structure identification seeks to identify …

A Selective retinoid X receptor agonist bexarotene (targretin) prevents and overcomes acquired paclitaxel (Taxol) resistance in human non–small cell lung cancer

WC Yen, MR Corpuz, RY Prudente, TA Cooke… - Clinical cancer …, 2004 - AACR
Purpose: Paclitaxel is an important anticancer agent for the treatment of non–small cell lung
cancer (NSCLC). However, its use in cancer therapy is limited by development of acquired …

Differentiation and growth inhibition mediated via the RXR: PPARγ heterodimer in colon cancer

RM Cesario, J Stone, WC Yen, RP Bissonnette… - Cancer letters, 2006 - Elsevier
This study evaluated the anti-tumor efficacy of combining the RXR agonist, bexarotene, with
the PPARγ agonist, rosiglitazone, in colon cancer. Moser, a human colon cancer cell line, …