[HTML][HTML] Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction
…, SA Rosenthal, K Liu Kot, Y Liu, WW Yen… - PLoS …, 2020 - journals.plos.org
Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased
expression of the immune gene C4 has been linked to a greater risk of developing schizophrenia…
expression of the immune gene C4 has been linked to a greater risk of developing schizophrenia…
Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice
The opioid epidemic led to an increase in the number of neonatal opioid withdrawal syndrome
(NOWS) cases in infants born to opioid-dependent mothers. Hallmark features of NOWS …
(NOWS) cases in infants born to opioid-dependent mothers. Hallmark features of NOWS …
Highly unstable heterogeneous representations in VIP interneurons of the anterior cingulate cortex
C Johnson, LN Kretsge, WW Yen, B Sriram… - Molecular …, 2022 - nature.com
A hallmark of the anterior cingulate cortex (ACC) is its functional heterogeneity. Functional
and imaging studies revealed its importance in the encoding of anxiety-related and social …
and imaging studies revealed its importance in the encoding of anxiety-related and social …
[HTML][HTML] Dynamics and durability of HIV-1 neutralization are determined by viral replication
…, C Geldmacher, O Geisenberger, A Kroidl, W William… - Nature Medicine, 2023 - nature.com
Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent
infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet …
infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet …
A pipeline using bilateral in utero electroporation to interrogate genetic influences on rodent behavior
AL Comer, B Sriram, WW Yen, A Cruz-Martín - JoVE (Journal of Visualized …, 2020 - jove.com
As genome-wide association studies shed light on the heterogeneous genetic underpinnings
of many neurological diseases, the need to study the contribution of specific genes to brain …
of many neurological diseases, the need to study the contribution of specific genes to brain …
Distinct VIP interneurons in the cingulate cortex encode anxiogenic and social stimuli
C Johnson, LN Kretsge, WW Yen, B Sriram… - bioRxiv, 2020 - biorxiv.org
A hallmark of higher-order cortical regions is their functional heterogeneity, but it is not well
understood how these areas encode such diverse information. The anterior cingulate cortex (…
understood how these areas encode such diverse information. The anterior cingulate cortex (…
Stochastic optimization of multiple-reservoir-system operation
BPF Braga Jr, WWG Yen, L Becker… - Journal of Water …, 1991 - ascelibrary.org
A stochastic dynamic programming model for the optimization of hydropower prroduction of
a multiple storage‐reservoir system with correlated inflows has been developed. Application …
a multiple storage‐reservoir system with correlated inflows has been developed. Application …
A combinatorial optimization scheme for parameter structure identification in ground water modeling
FTC Tsai, NZ Sun, WWG Yen - Groundwater, 2003 - Wiley Online Library
This research develops a methodology for parameter structure identification in ground water
modeling. For a given set of observations, parameter structure identification seeks to identify …
modeling. For a given set of observations, parameter structure identification seeks to identify …
A Selective retinoid X receptor agonist bexarotene (targretin) prevents and overcomes acquired paclitaxel (Taxol) resistance in human non–small cell lung cancer
WC Yen, MR Corpuz, RY Prudente, TA Cooke… - Clinical cancer …, 2004 - AACR
Purpose: Paclitaxel is an important anticancer agent for the treatment of non–small cell lung
cancer (NSCLC). However, its use in cancer therapy is limited by development of acquired …
cancer (NSCLC). However, its use in cancer therapy is limited by development of acquired …
Differentiation and growth inhibition mediated via the RXR: PPARγ heterodimer in colon cancer
RM Cesario, J Stone, WC Yen, RP Bissonnette… - Cancer letters, 2006 - Elsevier
This study evaluated the anti-tumor efficacy of combining the RXR agonist, bexarotene, with
the PPARγ agonist, rosiglitazone, in colon cancer. Moser, a human colon cancer cell line, …
the PPARγ agonist, rosiglitazone, in colon cancer. Moser, a human colon cancer cell line, …