Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process

TL Kash, WP Nobis, RT Matthews… - Journal of …, 2008 - Soc Neuroscience
A common feature of drugs of abuse is their ability to increase extracellular dopamine levels
in key brain circuits. The actions of dopamine within these circuits are thought to be …

Amygdala‐stimulation‐induced apnea is attention and nasal‐breathing dependent

WP Nobis, S Schuele, JW Templer, G Zhou… - Annals of …, 2018 - Wiley Online Library
Objective Evidence suggests that disordered breathing is critically involved in Sudden
Unexpected Death in Epilepsy (SUDEP). To that end, evaluating structures that are activated by …

The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea

WP Nobis, KAG Otárula, JW Templer, EE Gerard… - Journal of …, 2019 - thejns.org
OBJECTIVE Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death
for patients with refractory epilepsy, and there is increasing evidence for a centrally mediated …

Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress

ZA McElligott, JR Klug, WP Nobis… - Proceedings of the …, 2010 - National Acad Sciences
Long-term depression (LTD) is an important synaptic mechanism for limiting excitatory
influence over circuits subserving cognitive and emotional behavior. A major means of LTD …

β-adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor–dependent and …

WP Nobis, TL Kash, Y Silberman, DG Winder - Biological psychiatry, 2011 - Elsevier
BACKGROUND: Evidence suggests that the noradrenergic and corticotrophin-releasing
factor (CRF) systems play critical roles in relapse and stress-related behaviors. In particular, …

Disruption of synaptic transmission in the bed nucleus of the stria terminalis reduces seizure-induced death in DBA/1 mice and alters brainstem E/I balance

…, K Preisinger, WW Yan, R Huffman, WP Nobis - ASN …, 2022 - journals.sagepub.com
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in refractory
epilepsy patients. Accumulating evidence from recent human studies and animal models …

[HTML][HTML] Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis

…, P Pandharipande, EW Ely, WP Nobis… - Brain, behavior, and …, 2023 - Elsevier
Sepsis and systemic inflammation are often accompanied by severe encephalopathy, sleep
disruption and delirium that strongly correlate with poor clinical outcomes including long-…

Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a Dravet syndrome mouse model

…, J Kearney, GT Swanson, D Chetkovich, WP Nobis - Eneuro, 2021 - eneuro.org
Dravet syndrome (DS) is a developmental and epileptic encephalopathy with an increased
incidence of sudden death. Evidence of interictal breathing deficits in DS suggests that …

Glucagon‐like peptide‐1 receptor differentially controls mossy cell activity across the dentate gyrus longitudinal axis

…, JE Biddinger, R Huffman, JE Ayala, WP Nobis… - …, 2022 - Wiley Online Library
Understanding the role of dentate gyrus (DG) mossy cells (MCs) in learning and memory
has rapidly evolved due to increasingly precise methods for targeting MCs and for in vivo …

Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer's disease

…, DC Consoli, MK Thibert, AB Bowman, WP Nobis… - Neurotoxicology, 2023 - Elsevier
Manganese (Mn) is an essential metal that serves as a cofactor for metalloenzymes important
in moderating oxidative stress and the glutamate/glutamine cycle. Mn is typically obtained …