User profiles for William J. Spencer
William J SpencerSUNY Upstate Medical University Verified email at upstate.edu Cited by 495 |
The Evolution of Industrial Research in the United States.
DA Hounshell, RS Rosenbloom, WJ Spencer - 1996 - books.google.com
Formally organized industrial research and development (R&D) in the United States has
existed for approximately a century. Depending upon how industrial R&D is defined, its first …
existed for approximately a century. Depending upon how industrial R&D is defined, its first …
[HTML][HTML] Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
…, J Wang, G Alexander, MA Cady, WJ Spencer… - Nature …, 2020 - nature.com
Genes encoding cell-surface proteins control nervous system development and are implicated
in neurological disorders. These genes produce alternative mRNA isoforms which remain …
in neurological disorders. These genes produce alternative mRNA isoforms which remain …
Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release
The primary cilium is a highly conserved organelle housing specialized molecules responsible
for receiving and processing extracellular signals. A recently discovered property shared …
for receiving and processing extracellular signals. A recently discovered property shared …
Photoreceptor discs: built like ectosomes
The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a
modified cilium filled with hundreds of flattened ‘disc' membranes that provide vast light-absorbing …
modified cilium filled with hundreds of flattened ‘disc' membranes that provide vast light-absorbing …
PRCD is essential for high-fidelity photoreceptor disc formation
Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive
disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has …
disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has …
Photoreceptor disc membranes are formed through an Arp2/3-dependent lamellipodium-like mechanism
WJ Spencer, TR Lewis, S Phan… - Proceedings of the …, 2019 - National Acad Sciences
The light-sensitive outer segment of the vertebrate photoreceptor is a highly modified primary
cilium filled with disc-shaped membranes that provide a vast surface for efficient photon …
cilium filled with disc-shaped membranes that provide a vast surface for efficient photon …
Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration
NP Skiba, WJ Spencer, RY Salinas… - Journal of proteome …, 2013 - ACS Publications
Visual signal transduction takes place on the surface of flat membrane vesicles called
photoreceptor discs, which reside inside the light-sensitive outer segment organelle of vertebrate …
photoreceptor discs, which reside inside the light-sensitive outer segment organelle of vertebrate …
Absolute quantification of photoreceptor outer segment proteins
NP Skiba, TR Lewis, WJ Spencer… - Journal of proteome …, 2023 - ACS Publications
Photoreceptor cells generate neuronal signals in response to capturing light. This process,
called phototransduction, takes place in a highly specialized outer segment organelle. There …
called phototransduction, takes place in a highly specialized outer segment organelle. There …
SEMATECH after five years: high-technology consortia and US competitiveness
WJ Spencer, P Grindley - California Management Review, 1993 - journals.sagepub.com
Though there are many reasons for this decline. one of the most critical appears to be the
loss of US competitive capability in high-volume. lowcost manufacturing.'This has occurred …
loss of US competitive capability in high-volume. lowcost manufacturing.'This has occurred …
Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking
10.7554/eLife.12058.001 Sensory cilia are populated by a select group of signaling proteins
that detect environmental stimuli. How these molecules are delivered to the sensory cilium …
that detect environmental stimuli. How these molecules are delivered to the sensory cilium …