User profiles for William J. Spencer

William J Spencer

SUNY Upstate Medical University
Verified email at upstate.edu
Cited by 495

The Evolution of Industrial Research in the United States.

DA Hounshell, RS Rosenbloom, WJ Spencer - 1996 - books.google.com
Formally organized industrial research and development (R&D) in the United States has
existed for approximately a century. Depending upon how industrial R&D is defined, its first …

[HTML][HTML] Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease

…, J Wang, G Alexander, MA Cady, WJ Spencer… - Nature …, 2020 - nature.com
Genes encoding cell-surface proteins control nervous system development and are implicated
in neurological disorders. These genes produce alternative mRNA isoforms which remain …

Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release

RY Salinas, JN Pearring, JD Ding, WJ Spencer… - Journal of Cell …, 2017 - rupress.org
The primary cilium is a highly conserved organelle housing specialized molecules responsible
for receiving and processing extracellular signals. A recently discovered property shared …

Photoreceptor discs: built like ectosomes

WJ Spencer, TR Lewis, JN Pearring, VY Arshavsky - Trends in cell biology, 2020 - cell.com
The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a
modified cilium filled with hundreds of flattened ‘disc' membranes that provide vast light-absorbing …

PRCD is essential for high-fidelity photoreceptor disc formation

WJ Spencer, JD Ding, TR Lewis, C Yu… - Proceedings of the …, 2019 - National Acad Sciences
Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive
disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has …

Photoreceptor disc membranes are formed through an Arp2/3-dependent lamellipodium-like mechanism

WJ Spencer, TR Lewis, S Phan… - Proceedings of the …, 2019 - National Acad Sciences
The light-sensitive outer segment of the vertebrate photoreceptor is a highly modified primary
cilium filled with disc-shaped membranes that provide a vast surface for efficient photon …

Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration

NP Skiba, WJ Spencer, RY Salinas… - Journal of proteome …, 2013 - ACS Publications
Visual signal transduction takes place on the surface of flat membrane vesicles called
photoreceptor discs, which reside inside the light-sensitive outer segment organelle of vertebrate …

Absolute quantification of photoreceptor outer segment proteins

NP Skiba, TR Lewis, WJ Spencer… - Journal of proteome …, 2023 - ACS Publications
Photoreceptor cells generate neuronal signals in response to capturing light. This process,
called phototransduction, takes place in a highly specialized outer segment organelle. There …

SEMATECH after five years: high-technology consortia and US competitiveness

WJ Spencer, P Grindley - California Management Review, 1993 - journals.sagepub.com
Though there are many reasons for this decline. one of the most critical appears to be the
loss of US competitive capability in high-volume. lowcost manufacturing.'This has occurred …

Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking

JN Pearring, WJ Spencer, EC Lieu, VY Arshavsky - Elife, 2015 - elifesciences.org
10.7554/eLife.12058.001 Sensory cilia are populated by a select group of signaling proteins
that detect environmental stimuli. How these molecules are delivered to the sensory cilium …