User profiles for Wayne D. Bowen

Wayne Bowen

Professor of Biology and Chair, Department of Molecular Pharmacology, Physiology & …
Verified email at brown.edu
Cited by 14753

Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines

BJ Vilner, CS John, WD Bowen - Cancer research, 1995 - AACR
Thirteen tumor-derived cell lines of human and nonhuman origin and from various tissues
were examined for the presence and density of sigma-1 and sigma-2 receptors. Sigma-1 …

Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling

…, G Feinstein, J Orringer, W Williams, WD Bowen - European Journal of …, 1994 - Elsevier
Rat liver and kidney were investigated for the presence of sigma (σ) receptor subtypes by
radioligand binding with three highly selective σ probes and by photoaffinity labeling using [H]…

A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma …

SB Hellewell, WD Bowen - Brain research, 1990 - Elsevier
Two highly selective radiolabeled probes for sigma receptors were found to bind with high
affinity and capacity to membranes from undifferentiated PC12 cells. [ 3 H]1,3-di-o-…

Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines

KW Crawford, WD Bowen - Cancer research, 2002 - AACR
We have reported previously that sigma-2 receptors are expressed in high densities in a
variety of tumor cell types (BJ Vilner et al., Cancer Res., 55: 408–413, 1995) and that various …

Sigma receptors: recent advances and new clinical potentials

WD Bowen - Pharmaceutica Acta Helvetiae, 2000 - Elsevier
Several recent advances are leading to a better understanding of sigma receptors. Here we
focus on our recent findings regarding cellular functions of sigma-2 receptors and discuss …

Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism

RR Matsumoto, WD Bowen, MA Tom… - European journal of …, 1995 - Elsevier
The novel σ receptor ligands, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine
(BD1047) and 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine (BD1063), were …

Modulation of cellular calcium by sigma-2 receptors: release from intracellular stores in human SK-N-SH neuroblastoma cells

BJ Vilner, WD Bowen - Journal of Pharmacology and Experimental …, 2000 - ASPET
Human SK-N-SH neuroblastoma cells expressed sigma-1 and sigma-2 receptors with similar
pharmacological profiles to those of rodent-derived tissues, although sigma-2 receptors …

Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability

BJ Vilner, BR de Costa, WD Bowen - Journal of Neuroscience, 1995 - Soc Neuroscience
The morphological effects of several neuroleptics as well as other novel and prototypic sigma
ligands were examined by addition to cultures of C6 glioma cells. Sigma ligands caused …

[HTML][HTML] Role of sigma-1 receptor C-terminal segment in inositol 1, 4, 5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 …

Z Wu, WD Bowen - Journal of biological chemistry, 2008 - ASBMB
Sigma-1 receptor (sigma-1R) agonists enhance inositol 1,4,5-trisphosphate (IP 3 )-dependent
calcium release from endoplasmic reticulum by inducing dissociation of ankyrin B 220 (…

Targeting Sigma Receptor-binding Benzamides as in Vivo Diagnostic and Therapeutic Agents for Human Prostate Tumors

CS John, BJ Vilner, BC Geyer, T Moody, WD Bowen - Cancer research, 1999 - AACR
Sigma receptors are known to be expressed in a variety of human tumor cells, including
breast, neural, and melanoma tumors. A very high density (1.0–1.5 million receptors/cell) of …