The extent of microglial heterogeneity in humans remains a central yet poorly explored question
in light of the development of therapies targeting this cell type. Here, we investigate the …

Nervous systems are composed of various cell types, but the extent of cell type diversity is
poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

The structure and function of the human brain are highly stereotyped, implying a conserved
molecular program responsible for its development, cellular structure and function. We …

Aging is characterized by an increased vulnerability to infection and the development of
inflammatory diseases, such as atherosclerosis, frailty, cancer and neurodegeneration. Here, we …

There is a high diversity of neuronal types in the mammalian neocortex. To facilitate
construction of system models with multiple cell types, we generate a database of point models …

INTRODUCTION Brain function is often compared to an orchestral ensemble, where
subgroups of neurons that have similar activity are analogous to different types of instruments …

The neocortex contains a multitude of cell types that are segregated into layers and functionally
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …

The brain is an organ of immense complexity. Next-generation RNA sequencing (RNA-seq)
is becoming increasingly popular in the deconstruction of this complexity into distinct classes …

The manner in which different distributions of synaptic weights onto cortical neurons shape
their spiking activity remains open. To characterize a homogeneous neuronal population, we …