User profiles for V. L. Dawson
Valina L. DawsonProfessor of Neurology, Neuroscience and Physiology, Johns Hopkins University School of … Verified email at jhmi.edu Cited by 116980 |
[HTML][HTML] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …
guidelines for the definition and interpretation of cell death from morphological, biochemical, …
[HTML][HTML] Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations
for the definition of distinct cell death morphologies and for the appropriate use of cell …
for the definition of distinct cell death morphologies and for the appropriate use of cell …
Molecular pathways of neurodegeneration in Parkinson's disease
Parkinson's disease (PD) is a complex disorder with many different causes, yet they may
intersect in common pathways, raising the possibility that neuroprotective agents may have …
intersect in common pathways, raising the possibility that neuroprotective agents may have …
Neurotoxic reactive astrocytes are induced by activated microglia
Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease,
but their role is poorly understood. Here we show that a subtype of reactive astrocytes, …
but their role is poorly understood. Here we show that a subtype of reactive astrocytes, …
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels,
cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate …
cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate …
Mediation of poly (ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA
damage surveillance network. PARP-1 is also a mediator of cell death after ischemia-…
damage surveillance network. PARP-1 is also a mediator of cell death after ischemia-…
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARK2/Parkin
mutations cause autosomal recessive forms of Parkinson's disease. Upon a loss of …
mutations cause autosomal recessive forms of Parkinson's disease. Upon a loss of …
Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity
Poly(adenosine 5′-diphosphoribose) synthetase (PARS) is a nuclear enzyme which, when
activated by DNA strand breaks, adds up to 100 adenosine 5′-diphosphoribose (ADP-…
activated by DNA strand breaks, adds up to 100 adenosine 5′-diphosphoribose (ADP-…
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
… acidic protein (GFAP) immunocytochemical staining of neurons and astrocytes, respectively
(VL Dawson, TM Dawson, DA Bartley, GR Uhl, and SH Snyder, unpublished observations). …
(VL Dawson, TM Dawson, DA Bartley, GR Uhl, and SH Snyder, unpublished observations). …
Molecular pathophysiology of Parkinson's disease
… there is a significant genetic component to disease (Dawson & Dawson 2003, Hicks et al.
2002, … 273:9443–49 Dawson TM, Dawson VL. 2003. Rare genetic mutations shed light on the …
2002, … 273:9443–49 Dawson TM, Dawson VL. 2003. Rare genetic mutations shed light on the …