User profiles for V. L. Dawson

Valina L. Dawson

Professor of Neurology, Neuroscience and Physiology, Johns Hopkins University School of …
Verified email at jhmi.edu
Cited by 116980

[HTML][HTML] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

…, V D'angiolella, TM Dawson, VL Dawson… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …

[HTML][HTML] Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

…, MV Blagosklonny, TM Dawson, VL Dawson… - Cell Death & …, 2012 - nature.com
In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations
for the definition of distinct cell death morphologies and for the appropriate use of cell …

Molecular pathways of neurodegeneration in Parkinson's disease

TM Dawson, VL Dawson - Science, 2003 - science.org
Parkinson's disease (PD) is a complex disorder with many different causes, yet they may
intersect in common pathways, raising the possibility that neuroprotective agents may have …

Neurotoxic reactive astrocytes are induced by activated microglia

…, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson… - Nature, 2017 - nature.com
Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease,
but their role is poorly understood. Here we show that a subtype of reactive astrocytes, …

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

VL Dawson, TM Dawson, ED London… - Proceedings of the …, 1991 - National Acad Sciences
Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels,
cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate …

Mediation of poly (ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

…, HJ Federoff, GG Poirier, TM Dawson, VL Dawson - Science, 2002 - science.org
Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA
damage surveillance network. PARP-1 is also a mediator of cell death after ischemia-…

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

…, VL Dawson, R Grailhe, TM Dawson… - Proceedings of the …, 2010 - National Acad Sciences
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARK2/Parkin
mutations cause autosomal recessive forms of Parkinson's disease. Upon a loss of …

Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity

J Zhang, VL Dawson, TM Dawson, SH Snyder - Science, 1994 - science.org
Poly(adenosine 5′-diphosphoribose) synthetase (PARS) is a nuclear enzyme which, when
activated by DNA strand breaks, adds up to 100 adenosine 5′-diphosphoribose (ADP-…

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

VL Dawson, TM Dawson, DA Bartley… - Journal of …, 1993 - Soc Neuroscience
… acidic protein (GFAP) immunocytochemical staining of neurons and astrocytes, respectively
(VL Dawson, TM Dawson, DA Bartley, GR Uhl, and SH Snyder, unpublished observations). …

Molecular pathophysiology of Parkinson's disease

…, AB West, VL Dawson, TM Dawson - Annu. Rev …, 2005 - annualreviews.org
… there is a significant genetic component to disease (Dawson & Dawson 2003, Hicks et al.
2002, … 273:9443–49 Dawson TM, Dawson VL. 2003. Rare genetic mutations shed light on the …