KLHL7 promotes TUT1 ubiquitination associated with nucleolar integrity: implications for retinitis pigmentosa

J Kim, F Tsuruta, T Okajima, S Yano, B Sato… - … and biophysical research …, 2017 - Elsevier
Kelch-like protein 7 (KLHL7) is a component of Cul3-based Cullin-RING ubiquitin ligase.
Recent studies have revealed that mutations in klhl7 gene cause several disorders, such as …

USP15 deubiquitinates TUT1 associated with RNA metabolism and maintains cerebellar homeostasis

…, T Taketomi, S Yano, T Okajima… - … and Cellular Biology, 2020 - Taylor & Francis
Precise regulation of RNA metabolism is crucial for dynamic gene expression and controlling
cellular functions. In the nervous system, defects in RNA metabolism are implicated in the …

[HTML][HTML] Microglial dynamics during brain development

T Okajima, F Tsuruta - Neural Regeneration Research, 2018 - journals.lww.com
Microglia are the resident immune cells of the central nervous system (CNS). In the normal
state, microglia have a ramified shape and continuously survey the conditions of the brain. In …

CACUL1/CAC1 attenuates p53 activity through PML post-translational modification

…, T Naganuma, A Kazaana, T Okajima… - Biochemical and …, 2017 - Elsevier
Promyelocytic leukaemia (PML) is a tumor suppressor protein covalently conjugated with
SUMO family proteins, leading to the formation of PML nuclear bodies (NBs). PML-NBs provide …

Quantification of endosome and lysosome motilities in cultured neurons using fluorescent probes

F Tsuruta, T Okajima, S Yano, T Chiba - JoVE (Journal of Visualized …, 2017 - jove.com
In the brain, membrane trafficking systems play important roles in regulating neuronal functions,
such as neuronal morphology, synaptic plasticity, survival, and glial communications. To …

Atypical cadherin FAT3 is a novel mediator for morphological changes of microglia

T Okajima, Y Gu, R Teruya, S Yano, T Taketomi, B Sato… - eneuro, 2020 - eneuro.org
Microglia are resident macrophages that are critical for brain development and homeostasis.
Microglial morphology is dynamically changed during postnatal stages, leading to …

Propagation of neuronal micronuclei regulates microglial states

…, M Saeki, C Maeda, K Akiyama, T Okajima-Takahashi… - bioRxiv, 2023 - biorxiv.org
Microglia, resident immune cells in the central nervous system, undergo morphological and
functional changes in response to signals from the local environment and mature into …

[HTML][HTML] Exploring genes that control microglial heterogeneity and transition

T Okajima, F Tsuruta - Neural Regeneration Research, 2021 - journals.lww.com
Microglia, which comprise approximately 10% of total cells in the brain, are the resident
immune cells in the central nervous system and contribute to maintaining the brain homeostasis …

Performing Childhood in Diaspora: Palimpsestic Bodies and Agency in Contemporary Black Diasporic Literature

K Okajima - 2018 - search.proquest.com
… My son Yu Okajima, who was born when this project was still half written and who has … My
profoundest debt is to my wife Tomomi Okajima, who moved to Buffalo with me since 2010 and …

[HTML][HTML] Replication Study for the Association of Five SNPs Identified by GWAS and Trastuzumab-Induced Cardiotoxicity in Japanese and Singaporean Cohorts

C Udagawa, S Kuah, T Shimoi, K Kato… - Biological and …, 2022 - jstage.jst.go.jp
Tomomi Okajima for their contribution to the collection of clinical information, and Dr. Hiromi
Sakamoto and all staff at the National Cancer Center Hospital, and National Cancer Center …