The dentate gyrus of the hippocampus continues to produce new neurons throughout
adulthood. Adult neurogenesis has been linked to hippocampal function, including learning and …

Background Hippocampal volume loss is a hallmark of clinical depression. Chronic stress
produces volume loss in the hippocampus in humans and atrophy of CA3 pyramidal cells and …

Several lines of evidence suggest that adult neurogenesis, the production of new neurons
in adulthood, may play a role in psychiatric disorders, including depression, anxiety, and …

Physical exercise is known to reduce anxiety. The ventral hippocampus has been linked to
anxiety regulation but the effects of running on this subregion of the hippocampus have been …

Unpredictable aversive experiences, or stressors, lead to changes in depression- and
anxiety-related behavior and to changes in hippocampal structure including decreases in adult …

Stress is known to inhibit neuronal growth in the hippocampus. In addition to reducing the
size and complexity of the dendritic tree, stress and elevated glucocorticoid levels are known …

Numerous studies have attempted to determine the function of adult neurogenesis in the
hippocampus using methods to deplete new neurons and examine changes in behaviors …

Research on social instability has focused on its detrimental consequences, but most people
are resilient and respond by invoking various coping strategies. To investigate cellular …

Virtually all antidepressant agents increase the birth of granule neurons in the adult dentate
gyrus in rodents, providing a key basis for the neurogenesis hypothesis of antidepressant …

Fear learning is highly adaptive if utilized in appropriate situations but can lead to generalized
anxiety if applied too widely. A role of predictive cues in inhibiting fear generalization has …