User profiles for Tim Vanuytsel

Tim Vanuytsel

Verified email at med.kuleuven.be
Cited by 7739

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia

H Vanheel, M Vicario, T Vanuytsel, L Van Oudenhove… - Gut, 2014 - gut.bmj.com
Objective Functional dyspepsia (FD) is an extremely common functional gastrointestinal
disorder, the pathophysiology of which is poorly understood. We hypothesised that impaired …

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

T Vanuytsel, S Van Wanrooy, H Vanheel… - Gut, 2014 - gut.bmj.com
Objective Intestinal permeability and psychological stress have been implicated in the
pathophysiology of IBD and IBS. Studies in animals suggest that stress increases permeability via …

[HTML][HTML] Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review

…, N Steenackers, NL Trevaskis, T Vanuytsel… - European Journal of …, 2021 - Elsevier
The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

[PDF][PDF] Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

…, S Klein, IV Elst, P Windmolders, T Vanuytsel… - …, 2014 - Wiley Online Library
The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid
homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease. We …

[HTML][HTML] International consensus on the diagnosis and management of dumping syndrome

…, H Suzuki, A Ukleja, A Van Beek, T Vanuytsel… - Nature Reviews …, 2020 - nature.com
Dumping syndrome is a common but underdiagnosed complication of gastric and oesophageal
surgery. We initiated a Delphi consensus process with international multidisciplinary …

[HTML][HTML] The role of intestinal permeability in gastrointestinal disorders and current methods of evaluation

T Vanuytsel, J Tack, R Farre - Frontiers in Nutrition, 2021 - frontiersin.org
An increased intestinal permeability has been described in various gastrointestinal and non-gastrointestinal
disorders. Nevertheless, the concept and definition of intestinal permeability …

Long-term outcome of pneumatic dilation in the treatment of achalasia

M Hulselmans, T Vanuytsel, T Degreef, D Sifrim… - Clinical …, 2010 - Elsevier
BACKGROUND & AIMS: Achalasia is treated with pneumatic dilation or Heller myotomy, but
studies suggest poor long-term outcomes. We analyzed long-term outcomes after initial …

[HTML][HTML] Efficacy of budesonide orodispersible tablets as induction therapy for eosinophilic esophagitis in a randomized placebo-controlled trial

…, R Greinwald, A Schoepfer, A Straumann, T Vanuytsel… - Gastroenterology, 2019 - Elsevier
Background & Aims Swallowed topical-acting corticosteroids are recommended as first-line
therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized for …

Novel concepts in the pathophysiology and treatment of functional dyspepsia

L Wauters, NJ Talley, MM Walker, J Tack, T Vanuytsel - Gut, 2020 - gut.bmj.com
Emerging data increasingly point towards the duodenum as a key region underlying the
pathophysiology of functional dyspepsia (FD), one of the most prevalent functional GI disorders. …

[HTML][HTML] Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review

…, J Rubbens, J Van Den Αbeele, T Vanuytsel… - European journal of …, 2019 - Elsevier
Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …