Many psychiatric and neurological disorders are characterized by learning and memory
deficits, for which cognitive enhancement is considered a valid treatment strategy. The N-methyl-…

NHE-RF, a regulatory cofactor for NHE (Na + -H + exchanger) type 3, interacts with ion
transporters and receptors through its PDZ domains and with the MERM proteins (merlin, ezrin, …

The 56-kDa B1 subunit of the vacuolar H + ATPase has a C-terminal DTAL amino acid motif
typical of PDZ-binding proteins that associate with the PDZ protein, NHE-RF (Na + /H + …

Merlin, the neurofibromatosis 2 tumor suppressor protein, has two major isoforms with
alternate C termini and is related to the ERM (ezrin, radixin, moesin) proteins. Regulation of the …

Neurofibromatosis 2 (NF2) is a dominantly inherited disorder characterized by bilateral
vestibular schwannomas and meningiomas. Merlin, the neurofibromatosis 2 tumor suppressor …

Disparities in cancer patient responses have prompted widespread searches to identify
differences in sensitive vs. nonsensitive populations and form the basis of personalized medicine…

Metabolic dysfunction mutations can impair energy sensing and cause cancer. Loss of
function of the mitochondrial tricarboxylic acid (TCA) cycle enzyme subunit succinate …

Millions of traumatic brain injuries (TBIs) occur annually. TBIs commonly result from falls,
traffic accidents, and sports-related injuries, all of which involve rotational acceleration/…

Injury to the CNS induces astrogliosis, an astrocyte-mediated response that has both
beneficial and detrimental impacts on surrounding neural and non-neural cells. The precise …

The phosphoinositide 3-kinase p110α is an essential mediator of insulin signaling and
glucose homeostasis. We interrogated the human serine, threonine, and tyrosine kinome to …