User profiles for Theodore R. Cummins

Theodore Cummins

Other name: Theodore R Cummins
Professor of Biology, Indiana University Indianapolis
Verified email at iu.edu
Cited by 19482

Sodium channels in normal and pathological pain

SD Dib-Hajj, TR Cummins, JA Black… - Annual review of …, 2010 - annualreviews.org
Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Na v 1.1–Na v 1.9, are …

Contribution of Nav1.8 Sodium Channels to Action Potential Electrogenesis in DRG Neurons

M Renganathan, TR Cummins… - Journal of …, 2001 - journals.physiology.org
C-type dorsal root ganglion (DRG) neurons can generate tetrodotoxin-resistant (TTX-R)
sodium-dependent action potentials. However, multiple sodium channels are expressed in these …

Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons …

TR Cummins, SG Waxman - Journal of Neuroscience, 1997 - Soc Neuroscience
Clinical and experimental studies have shown that spinal sensory neurons become
hyperexcitable after axonal injury, and electrophysiological changes have suggested that this may …

The roles of sodium channels in nociception: implications for mechanisms of pain

TR Cummins, PL Sheets, SG Waxman - Pain, 2007 - Elsevier
Understanding the role of voltage-gated sodium channels in nociception may provide important
insights into pain mechanisms. Voltage-gated sodium channels are critically important …

[PDF][PDF] A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons

TR Cummins, SD Dib-Hajj, JA Black… - The Journal of …, 1999 - Soc Neuroscience
TTX-resistant (TTX-R) sodium currents are preferentially expressed in small C-type dorsal
root ganglion (DRG) neurons, which include nociceptive neurons. Two mRNAs that are …

Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain

JA Black, S Liu, M Tanaka, TR Cummins, SG Waxman - Pain, 2004 - journals.lww.com
Nociceptive neurons within dorsal root ganglia (DRG) express multiple voltage-gated
sodium channels, of which the tetrodotoxin-resistant (TTX-R) channel Na v 1.8 has been …

Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons

AM Rush, TR Cummins… - The Journal of physiology, 2007 - Wiley Online Library
Dorsal root ganglion neurons express an array of sodium channel isoforms allowing precise
control of excitability. An increasing body of literature indicates that regulation of firing …

Electrophysiological properties of mutant Nav1. 7 sodium channels in a painful inherited neuropathy

TR Cummins, SD Dib-Hajj… - Journal of Neuroscience, 2004 - Soc Neuroscience
Although the physiological basis of erythermalgia, an autosomal dominant painful neuropathy
characterized by redness of the skin and intermittent burning sensation of extremities, is …

A single sodium channel mutation produces hyper-or hypoexcitability in different types of neurons

…, SD Dib-Hajj, S Liu, TR Cummins… - Proceedings of the …, 2006 - National Acad Sciences
Disease-producing mutations of ion channels are usually characterized as producing
hyperexcitability or hypoexcitability. We show here that a single mutation can produce …

[HTML][HTML] The role of sodium channels in chronic inflammatory and neuropathic pain

R Amir, CE Argoff, GJ Bennett, TR Cummins… - The Journal of …, 2006 - Elsevier
Clinical and experimental data indicate that changes in the expression of voltage-gated
sodium channels play a key role in the pathogenesis of neuropathic pain and that drugs that …