Post-stroke functional recovery can occur spontaneously during the subacute phase;
however, how post-stroke fibrotic repair affects functional recovery is highly debated. Platelet-…

Activation of the superoxide-producing phagocyte NADPH oxidase requires interaction
between p47 phox and p22 phox , which is mediated via the SH3 domains of the former protein. …

Autophagy is an intracellular bulk degradation process whereby cytoplasmic proteins and
organelles are degraded and recycled through lysosomes. In the heart, autophagy plays a …

The NADPH oxidases (Nox) are transmembrane proteins dedicated to producing reactive
oxygen species (ROS), including superoxide and hydrogen peroxide, by transferring electrons …

Background— Recent evidence has suggested that reactive oxygen species are important
signaling molecules in vascular cells and play a pivotal role in the development of vascular …

Post‐ischemic inflammation is an essential step in the progression of ischemic stroke. This
review focuses on the function of infiltrating immune cells, macrophages, and T cells, in …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Background: Gastrointestinal (GI) hemorrhage is a potentially serious complication of acute
stroke, but its incidence appears to be decreasing. The aim of this study was to elucidate the …

Background and Purpose— Recent studies show that successful endovascular thrombectomy
6 to 12 hours after stroke onset enhances functional outcomes 3 months later. In this study…

NAD(P)H oxidases (Noxs) produce O 2 − and play an important role in cardiovascular
pathophysiology. The Nox4 isoform is expressed primarily in the mitochondria in cardiac myocytes…