SUMO modification of Huntingtin and Huntington's disease pathology
…, LC Trotman, N Slepko, K Illes, T Lukacsovich… - Science, 2004 - science.org
Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein,
Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a …
Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a …
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
…, JG O'Rourke, H Khashwji, T Lukacsovich… - Journal of Cell …, 2009 - rupress.org
Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's
disease, a neurodegenerative disease associated with aging and the accumulation of …
disease, a neurodegenerative disease associated with aging and the accumulation of …
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
J Pallos, L Bodai, T Lukacsovich… - Human molecular …, 2008 - academic.oup.com
Huntington’s disease (HD) is associated with transcriptional dysregulation, and multiple studies
with histone deacetylase (HDAC) inhibitors suggest that global approaches for restoring …
with histone deacetylase (HDAC) inhibitors suggest that global approaches for restoring …
[HTML][HTML] Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity
…, CM Guerrero, H Khashwji, T Lukacsovich… - Journal of Biological …, 2009 - ASBMB
Huntingtin (Htt) is a widely expressed protein that causes tissue-specific degeneration when
mutated to contain an expanded polyglutamine (poly(Q)) domain. Although Htt is large, 350 …
mutated to contain an expanded polyglutamine (poly(Q)) domain. Although Htt is large, 350 …
[HTML][HTML] Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
Background Age-related neurodegenerative diseases share a number of important pathological
features, such as accumulation of misfolded proteins as amyloid oligomers and fibrils. …
features, such as accumulation of misfolded proteins as amyloid oligomers and fibrils. …
Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression
The Drosophila fruitless (fru) gene product Fru has been postulated to be a neural sex-determination
factor that directs the development of at least two male-specific characteristics, …
factor that directs the development of at least two male-specific characteristics, …
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease
MR Smith, A Syed, T Lukacsovich… - Human molecular …, 2014 - academic.oup.com
Protein acetylation, which is central to transcriptional control as well as other cellular
processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation …
processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation …
Mutations in the Novel Membrane Protein Spinster Interfere with Programmed Cell Death and Cause Neural Degeneration in Drosophila melanogaster
…, K Usui-Aoki, L Shimoda, T Lukacsovich… - … and cellular biology, 2001 - Taylor & Francis
Mutations in the spin gene are characterized by an extraordinarily strong rejection behavior
of female flies in response to male courtship. They are also accompanied by decreases in …
of female flies in response to male courtship. They are also accompanied by decreases in …
[PDF][PDF] Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes
The hemocytes, the blood cells of Drosophila, participate in the humoral and cellular immune
defense reactions against microbes and parasites [1–8]. The plasmatocytes, one class of …
defense reactions against microbes and parasites [1–8]. The plasmatocytes, one class of …
[PDF][PDF] A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis
G Ossato, MA Digman, C Aiken, T Lukacsovich… - Biophysical journal, 2010 - cell.com
Protein aggregation is a hallmark of several neurodegenerative diseases including Huntington's
disease. We describe the use of the recently developed number and brightness method …
disease. We describe the use of the recently developed number and brightness method …