[PDF][PDF] An imbalancing act: gap junctions reduce the backward motor circuit activity to bias C. elegans for forward locomotion

T Kawano, MD Po, S Gao, G Leung, WS Ryu, M Zhen - Neuron, 2011 - cell.com
A neural network can sustain and switch between different activity patterns to execute multiple
behaviors. By monitoring the decision making for directional locomotion through motor …

[PDF][PDF] Proprioceptive coupling within motor neurons drives C. elegans forward locomotion

…, AM Leifer, V Butler, C Fang-Yen, T Kawano… - neuron, 2012 - cell.com
Locomotion requires coordinated motor activity throughout an animal's body. In both vertebrates
and invertebrates, chains of coupled central pattern generators (CPGs) are commonly …

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

T Murakami, SP Yang, L Xie, T Kawano… - Human molecular …, 2012 - academic.oup.com
It is unclear whether mutations in fused in sarcoma (FUS) cause familial amyotrophic lateral
sclerosis via a loss-of-function effect due to titrating FUS from the nucleus or a gain-of-…

Excitatory motor neurons are local oscillators for backward locomotion

S Gao, SA Guan, AD Fouad, J Meng, T Kawano… - Elife, 2018 - elifesciences.org
10.7554/eLife.29915.001 Cell- or network-driven oscillators underlie motor rhythmicity. The
identity of C. elegans oscillators remains unknown. Through cell ablation, electrophysiology, …

Descending pathway facilitates undulatory wave propagation in Caenorhabditis elegans through gap junctions

T Xu, J Huo, S Shao, M Po, T Kawano… - Proceedings of the …, 2018 - National Acad Sciences
Descending signals from the brain play critical roles in controlling and modulating locomotion
kinematics. In the Caenorhabditis elegans nervous system, descending AVB premotor …

Identification of genes involved in synaptogenesis using a fluorescent active zone marker in Caenorhabditis elegans

E Yeh, T Kawano, RM Weimer… - Journal of …, 2005 - Soc Neuroscience
Active zones are presynaptic regions where synaptic vesicles fuse with plasma membrane
to release neurotransmitters. Active zones are highly organized structurally and are …

[HTML][HTML] The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion

S Gao, L Xie, T Kawano, MD Po, JK Pirri… - Nature …, 2015 - nature.com
Persistent neural activity, a sustained circuit output that outlasts the stimuli, underlies short-term
or working memory, as well as various mental representations. Molecular mechanisms …

[PDF][PDF] ER proteostasis regulators cell-non-autonomously control sleep

T Kawano, M Kashiwagi, M Kanuka, CK Chen… - Cell Reports, 2023 - cell.com
Sleep is regulated by peripheral tissues under fatigue. The molecular pathways in peripheral
cells that trigger systemic sleep-related signals, however, are unclear. Here, a forward …

An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans

…, Q Wen, H Liu, C Zhong, Y Qin, G Harris, T Kawano… - Elife, 2016 - elifesciences.org
10.7554/eLife.14197.001 As a common neurotransmitter in the nervous system, γ-aminobutyric
acid (GABA) modulates locomotory patterns in both vertebrates and invertebrates. …

Morphological differences of choroid in central serous chorioretinopathy determined by ultra-widefield optical coherence tomography

T Izumi, I Maruko, T Kawano, M Sakaihara… - Graefe's Archive for …, 2022 - Springer
Purpose The purpose of this study was to compare the morphology of the central and peripheral
choroid of eyes with central serous chorioretinopathy (CSC) to that of normal eyes using …