Neurotrophic factors are promising candidates for the treatment of Parkinson's disease (PD).
Mesencephalic astrocyte-derived neurotrophic factor (MANF) belongs to a novel …

Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived
neurotrophic factor (MANF) constitute a novel, evolutionarily conserved family of neurotrophic …

Cerebral dopamine neurotrophic factor ( CDNF ) protein has been shown to protect the
nigrostriatal dopaminergic pathway when given as intrastriatal infusions in rat and mouse models …

Retention of critical endoplasmic reticulum (ER) luminal proteins needed to carry out diverse
functions (eg, protein synthesis and folding, lipid metabolism) is mediated through a carboxy…

Historically, the rat has been the preferred animal model for behavioral studies. Limitations
in genome modification have, however, caused a lag in their use compared to the bevy of …

Drug addiction is a chronic brain disease and drugs of abuse cause long lasting
neuroadaptations. Addiction is characterized by the loss of control over drug use despite harmful …

Parkinson’s disease (PD) is a neurodegenerative disorder associated with a progressive
loss of dopaminergic (DAergic) neurons of the substantia nigra (SN) and the accumulation of …

Background & Aims Disruption to endoplasmic reticulum (ER) calcium homeostasis has been
implicated in obesity, however, the ability to longitudinally monitor ER calcium fluctuations …

Glial cell line-derived neurotrophic factor (GDNF) is one of the most studied neurotrophic
factors. GDNF has two splice isoforms, full-length pre-α-pro-GDNF (α-GDNF) and pre-β-pro-…

Endoplasmic reticulum (ER) dysregulation is associated with pathologies including
neurodegenerative, muscular, and diabetic conditions. Depletion of ER calcium can lead to the loss …