Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100
known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate …

In basic neuroscience research, data are often clustered or collected with repeated measures,
hence correlated. The most widely used methods such as t test and ANOVA do not take …

Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …

The study of Alzheimer’s Disease (AD) has traditionally focused on neuropathological
mechanisms that has guided therapies that attenuate neuropathological features. A new direction …

Objectives Sub‐anesthetic doses of ketamine have been found to provide rapid antidepressant
actions, indicating that the cellular signaling systems targeted by ketamine are potential …

Subanesthetic ketamine evokes rapid and long-lasting antidepressant effects in human
patients. The mechanism for ketamine's effects remains elusive, but ketamine may broadly …

Insulin-like growth factor 2 (IGF2) is abundantly expressed in the central nervous system (CNS).
Recent evidence highlights the role of IGF2 in the brain, sustained by data showing its …

Subanesthetic ketamine evokes rapid antidepressant effects in human patients that persist
long past ketamine’s chemical half-life of ~2 h. Ketamine’s sustained antidepressant action …

Hilar mossy cells are the prominent glutamatergic cell type in the dentate hilus of the dentate
gyrus (DG); they have been proposed to have critical roles in the DG network. To better …

Inhibitory interneurons are crucial to brain function and their dysfunction is implicated in
neuropsychiatric conditions. Emerging evidence indicates that cholecystokinin (CCK)-…