Enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of VGLUT2 in midbrain dopamine neurons in mice

…, E Arvidsson, C Birgner, S Mahmoudi… - Journal of …, 2011 - Soc Neuroscience
The mesostriatal dopamine (DA) system contributes to several aspects of responses to rewarding
substances and is implicated in conditions such as drug addiction and eating disorders…

Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

…, CJA Smith-Anttila, S Mahmoudi… - Proceedings of the …, 2014 - National Acad Sciences
The subthalamic nucleus (STN) is a key area of the basal ganglia circuitry regulating movement.
We identified a subpopulation of neurons within this structure that coexpresses Vglut2 …

Upregulation of dopamine D3, not D2, receptors correlates with tardive dyskinesia in a primate model

S Mahmoudi, D Lévesque, PJ Blanchet - Movement Disorders, 2014 - Wiley Online Library
Tardive dyskinesia (TD) is a delayed and potentially irreversible motor complication arising
in patients chronically exposed to centrally active dopamine D2 receptor antagonists, …

Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid

S Mahmoudi, P Samadi, F Gilbert, B Ouattara… - Neurobiology of …, 2009 - Elsevier
We have previously shown that docosahexaenoic acid (DHA) significantly reduced L-Dopa-induced
dyskinesia (LID) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkeys (…

Reduced Vglut2/Slc17a6 gene expression levels throughout the mouse subthalamic nucleus cause cell loss and structural disorganization followed by increased …

…, K Nordenankar, E Arvidsson, S Mahmoudi… - eneuro, 2016 - eneuro.org
The subthalamic nucleus (STN) plays a central role in motor, cognitive, and affective behavior.
Deep brain stimulation (DBS) of the STN is the most common surgical intervention for …

Deficient striatal adaptation in aminergic and glutamatergic neurotransmission is associated with tardive dyskinesia in non-human primates exposed to antipsychotic …

C Lévesque, G Hernandez, S Mahmoudi, F Calon… - Neuroscience, 2017 - Elsevier
Tardive dyskinesia (TD) is a potentially disabling condition encompassing all delayed, persistent,
and often irreversible abnormal involuntary movements arising in a fraction of subjects …

Haloperidol‐induced striatal Nur77 expression in a non‐human primate model of tardive dyskinesia

S Mahmoudi, PJ Blanchet… - European Journal of …, 2013 - Wiley Online Library
Tardive dyskinesia ( TD ) is a delayed and potentially irreversible motor complication arising
in patients chronically exposed to antipsychotic drugs. As several modern (so‐called …

Tardive dyskinesia is associated with altered putamen Akt/GSK‐3β signaling in nonhuman primates

G Hernandez, S Mahmoudi, M Cyr, J Diaz… - Movement …, 2019 - Wiley Online Library
Background Tardive dyskinesia is a delayed and potentially irreversible motor complication
arising from chronic exposure to antipsychotic drugs. Interaction of antipsychotic drugs with …

Caractérisation pharmacologique et moléculaire des dyskinésies tardives chez un modèle de primate non humain

S Mahmoudi - 2014 - papyrus.bib.umontreal.ca
Les dyskinésies tardives (DT) sont des troubles moteurs associés à l’utilisation chronique
des antagonistes des récepteurs dopaminergiques D2 tels que les antipsychotiques et le …

Reduced consumption of sugar identifies a regulatory role for a Pitx2/Vglut2 co-expressing subpopulation in the structure and function of the mouse subthalamic …

…, K Nordenankar, E Arvidsson, S Mahmoudi… - 2016 - diva-portal.org
The basal ganglia are the key circuitry controlling movement and reward behavior. Both
locomotion and reward-related behavior are also modified by dopaminergic input from the …