Coordination between eye movement and whisking in head-fixed mice navigating a plus maze

R Bergmann, K Sehara, SE Dominiak, J Kremkow… - eneuro, 2022 - eneuro.org
Navigation through complex environments requires motor planning, motor preparation, and
the coordination between multiple sensory–motor modalities. For example, the stepping …

Whisking asymmetry signals motor preparation and the behavioral state of mice

SE Dominiak, MA Nashaat, K Sehara… - Journal of …, 2019 - Soc Neuroscience
A central function of the brain is to plan, predict, and imagine the effect of movement in a
dynamically changing environment. Here we show that in mice head-fixed in a plus-maze, …

[HTML][HTML] Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits

TG Heintz, AJ Hinojosa, SE Dominiak… - Nature …, 2022 - nature.com
Sensory processing in the cortex adapts to the history of stimulation but the mechanisms are
not understood. Imaging the primary visual cortex of mice we find here that an increase in …

Pixying behavior: a versatile real-time and post hoc automated optical tracking method for freely moving and head fixed animals

MA Nashaat, H Oraby, LB Peña, S Dominiak… - Eneuro, 2017 - eneuro.org
Here, we describe an automated optical method for tracking animal behavior in both head-fixed
and freely moving animals, in real time and offline. It takes advantage of an off-the-shelf …

[HTML][HTML] Optically induced calcium-dependent gene activation and labeling of active neurons using CaMPARI and Cal-Light

…, J Ledderose, TA Zolnik, SE Dominiak… - Frontiers in synaptic …, 2019 - frontiersin.org
The advent of optogenetic methods has made it possible to use endogeneously produced
molecules to image and manipulate cellular, subcellular, and synaptic activity. It has also led …

[HTML][HTML] Efficient training approaches for optimizing behavioral performance and reducing head fixation time

A Nasr, SE Dominiak, K Sehara, MA Nashaat… - Plos one, 2022 - journals.plos.org
The use of head fixation has become routine in systems neuroscience. However, whether
the behavior changes with head fixation, whether animals can learn aspects of a task while …

What moves when mice move a single whisker to touch? Individuality and stereotypy in behavior

M Staab, K Sehara, NL Bahr, SE Dominiak, ME Larkum… - bioRxiv, 2022 - biorxiv.org
A key function of the brain is to move the body through a rich, complex environment. When
rodents engage their environment, they move their whiskers as they extract tactile information. …

Refined movement analysis in the Staircase test reveals differential motor deficits in mouse models of stroke

…, R Paulat, J Lips, L Mosch, S Mueller, S Dominiak… - bioRxiv, 2023 - biorxiv.org
Accurate assessment of post-stroke deficits is vital in translational research. Recent
advances in machine learning provide unprecedented precision in quantifying rodent motor …

[PDF][PDF] Whisking signals motor preparation and the behavioral state of mice

SE Dominiak, MA Nashaat, K Sehara, H Oraby… - BioRxiv, 2019 - researchgate.net
A central function of the brain is to plan, predict and imagine the effect of movement in a
dynamically changing environment. Here we show that the position of the vibrissae, sets of …

Predicting behavior from eye movement and whisking asymmetry

R Bergmann, K Sehara, SE Dominiak, J Kremkow… - bioRxiv, 2021 - biorxiv.org
Navigation through complex environments requires motor planning, motor preparation and
the coordination between multiple sensory–motor modalities. For example, the stepping …