User profiles for Simone Chiola

Simone Chiola, MSc, PhD

Research Scientist, Sarafan ChEM-H, Stanford University
Verified email at stanford.edu
Cited by 172

[HTML][HTML] Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes

Y Wang, S Chiola, G Yang, C Russell… - Nature …, 2022 - nature.com
Human telencephalon is an evolutionarily advanced brain structure associated with many
uniquely human behaviors and disorders. However, cell lineages and molecular pathways …

[HTML][HTML] MicroRNA–mRNA interactions underlying colorectal cancer molecular subtypes

L Cantini, C Isella, C Petti, G Picco, S Chiola… - Nature …, 2015 - nature.com
Colorectal cancer (CRC) transcriptional subtypes have been recently identified by gene
expression profiling. Here we describe an analytical pipeline, microRNA master regulator …

Defective AMPA-mediated synaptic transmission and morphology in human neurons with hemizygous SHANK3 deletion engrafted in mouse prefrontal cortex

S Chiola, KL Napan, Y Wang, RM Lazarenko… - Molecular …, 2021 - nature.com
Genetic abnormalities in synaptic proteins are common in individuals with autism; however,
our understanding of the cellular and molecular mechanisms disrupted by these …

Foxg1 Overexpression in Neocortical Pyramids Stimulates Dendrite Elongation Via Hes1 and pCreb1 Upregulation

S Chiola, MD Do, L Centrone, A Mallamaci - Cerebral Cortex, 2019 - academic.oup.com
The architecture of neocortical projection neurons is subject of a complex gene control. Here
we demonstrated that Foxg1, a transcription factor gene which patterns the early rostral …

Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes

Y Wang, S Chiola, G Yang, C Russell, CJ Armstrong… - BioRxiv, 2021 - biorxiv.org
Our understanding of the human brain is limited by the lack of experimental models to
mechanistically probe the properties of brain cells at different developmental stages under normal …

iPSC toolbox for understanding and repairing disrupted brain circuits in autism

S Chiola, NU Edgar, A Shcheglovitov - Molecular psychiatry, 2022 - nature.com
Over the past decade, tremendous progress has been made in defining autism spectrum
disorder (ASD) as a disorder of brain connectivity. Indeed, whole-brain imaging studies …

Secreted reporter assay enables quantitative and longitudinal monitoring of neuronal activity

AC Santos, S Chiola, G Yang, A Shcheglovitov, S Park - Eneuro, 2021 - eneuro.org
The ability to measure changes in neuronal activity in a quantifiable and precise manner is
of fundamental importance to understand neuron development and function. Repeated …

Intraventricular transplantation of engineered neuronal precursors for in vivo neuroarchitecture studies

S Chiola, M Santo, A Mallamaci - JoVE (Journal of Visualized Experiments), 2019 - jove.com
Gene control of neuronal cytoarchitecture is currently the subject of intensive investigation.
Described here is a simple method developed to study in vivo gene control of neocortical …

Transcriptional changes consistent with altered neuronal differentiation, angiogenesis, and tumor plasticity induced in human subpallial telencephalic organoid …

S Chiola, J Yang, HMA Ullah, K Napan, Q Huang… - bioRxiv, 2023 - biorxiv.org
Glioblastoma multiforme (GBM) is one of the most aggressive and therapy-resistant brain
tumors prevalent in both adults and children. Despite extensive research to understand GBM …

[HTML][HTML] MMRA MicroRNA master regulator analysis

L Cantini, C Isella, C Petti, G Picco, S Chiola, E Ficarra… - 2015 - researchsquare.com
MMRA is an analysis pipeline that can be used for the identification of microRNAs driver of
cancer subtypes. It starts with (i) a paired microRNA/mRNA expression dataset (ii) …