User profiles for Simone Chiola
Simone Chiola, MSc, PhDResearch Scientist, Sarafan ChEM-H, Stanford University Verified email at stanford.edu Cited by 172 |
[HTML][HTML] Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes
Human telencephalon is an evolutionarily advanced brain structure associated with many
uniquely human behaviors and disorders. However, cell lineages and molecular pathways …
uniquely human behaviors and disorders. However, cell lineages and molecular pathways …
[HTML][HTML] MicroRNA–mRNA interactions underlying colorectal cancer molecular subtypes
Colorectal cancer (CRC) transcriptional subtypes have been recently identified by gene
expression profiling. Here we describe an analytical pipeline, microRNA master regulator …
expression profiling. Here we describe an analytical pipeline, microRNA master regulator …
Defective AMPA-mediated synaptic transmission and morphology in human neurons with hemizygous SHANK3 deletion engrafted in mouse prefrontal cortex
Genetic abnormalities in synaptic proteins are common in individuals with autism; however,
our understanding of the cellular and molecular mechanisms disrupted by these …
our understanding of the cellular and molecular mechanisms disrupted by these …
Foxg1 Overexpression in Neocortical Pyramids Stimulates Dendrite Elongation Via Hes1 and pCreb1 Upregulation
The architecture of neocortical projection neurons is subject of a complex gene control. Here
we demonstrated that Foxg1, a transcription factor gene which patterns the early rostral …
we demonstrated that Foxg1, a transcription factor gene which patterns the early rostral …
Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes
Our understanding of the human brain is limited by the lack of experimental models to
mechanistically probe the properties of brain cells at different developmental stages under normal …
mechanistically probe the properties of brain cells at different developmental stages under normal …
iPSC toolbox for understanding and repairing disrupted brain circuits in autism
S Chiola, NU Edgar, A Shcheglovitov - Molecular psychiatry, 2022 - nature.com
Over the past decade, tremendous progress has been made in defining autism spectrum
disorder (ASD) as a disorder of brain connectivity. Indeed, whole-brain imaging studies …
disorder (ASD) as a disorder of brain connectivity. Indeed, whole-brain imaging studies …
Secreted reporter assay enables quantitative and longitudinal monitoring of neuronal activity
The ability to measure changes in neuronal activity in a quantifiable and precise manner is
of fundamental importance to understand neuron development and function. Repeated …
of fundamental importance to understand neuron development and function. Repeated …
Intraventricular transplantation of engineered neuronal precursors for in vivo neuroarchitecture studies
Gene control of neuronal cytoarchitecture is currently the subject of intensive investigation.
Described here is a simple method developed to study in vivo gene control of neocortical …
Described here is a simple method developed to study in vivo gene control of neocortical …
Transcriptional changes consistent with altered neuronal differentiation, angiogenesis, and tumor plasticity induced in human subpallial telencephalic organoid …
Glioblastoma multiforme (GBM) is one of the most aggressive and therapy-resistant brain
tumors prevalent in both adults and children. Despite extensive research to understand GBM …
tumors prevalent in both adults and children. Despite extensive research to understand GBM …
[HTML][HTML] MMRA MicroRNA master regulator analysis
MMRA is an analysis pipeline that can be used for the identification of microRNAs driver of
cancer subtypes. It starts with (i) a paired microRNA/mRNA expression dataset (ii) …
cancer subtypes. It starts with (i) a paired microRNA/mRNA expression dataset (ii) …