User profiles for Sabato Santaniello

Sabato Santaniello

University of Connecticut
Verified email at uconn.edu
Cited by 1415

Physiology of functional and effective networks in epilepsy

…, DM Groppe, MA Kramer, CJ Chu, S Santaniello… - Clinical …, 2015 - Elsevier
Epilepsy is a network phenomenon characterized by atypical activity during seizure both at
the level of single neurons and neural populations. The etiology of epilepsy is not completely …

Network dynamics of the brain and influence of the epileptic seizure onset zone

SP Burns, S Santaniello, RB Yaffe… - Proceedings of the …, 2014 - National Acad Sciences
The human brain is a dynamic networked system. Patients with partial epileptic seizures have
focal regions that periodically diverge from normal brain network dynamics during seizures…

Closed-loop control of deep brain stimulation: a simulation study

S Santaniello, G Fiengo, L Glielmo… - IEEE Transactions on …, 2010 - ieeexplore.ieee.org
Deep brain stimulation (DBS) is an effective therapy to treat movement disorders including
essential tremor, dystonia, and Parkinson's disease. Despite over a decade of clinical …

Systems approaches to optimizing deep brain stimulation therapies in Parkinson's disease

S Santaniello, JT Gale, SV Sarma - … Reviews: Systems Biology …, 2018 - Wiley Online Library
Over the last 30 years, deep brain stimulation (DBS) has been used to treat chronic neurological
diseases like dystonia, obsessive–compulsive disorders, essential tremor, Parkinson’s …

[HTML][HTML] Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence

…, ES Boyden, M Barahona, S Santaniello… - Nature …, 2021 - nature.com
Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a
method to track the phase of neural oscillations in real-time via endpoint-corrected Hilbert …

Therapeutic mechanisms of high-frequency stimulation in Parkinson's disease and neural restoration via loop-based reinforcement

S Santaniello, MM McCarthy… - Proceedings of the …, 2015 - National Acad Sciences
High-frequency deep brain stimulation (HFS) is clinically recognized to treat parkinsonian
movement disorders, but its mechanisms remain elusive. Current hypotheses suggest that the …

[HTML][HTML] Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain-derived matrix

…, K Deisseroth, LD Black III, S Santaniello… - Scientific reports, 2019 - nature.com
Brain extracellular matrix (ECM) is often overlooked in vitro brain tissue models, despite its
instructive roles during development. Using developmental stage-sourced brain ECM in …

Role of cerebellar GABAergic dysfunctions in the origins of essential tremor

X Zhang, S Santaniello - Proceedings of the National …, 2019 - National Acad Sciences
Essential tremor (ET) is among the most prevalent movement disorders, but its origins are
elusive. The inferior olivary nucleus (ION) has been hypothesized as the prime generator of …

[HTML][HTML] Quickest detection of drug-resistant seizures: An optimal control approach

S Santaniello, SP Burns, AJ Golby, JM Singer… - Epilepsy & Behavior, 2011 - Elsevier
Epilepsy affects 50 million people worldwide, and seizures in 30% of the cases remain drug
resistant. This has increased interest in responsive neurostimulation, which is most effective …

KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons

…, K Springer, E Ortiz, H Soh, S Santaniello… - Journal of …, 2023 - Soc Neuroscience
Gain-of-function (GOF) pathogenic variants in the potassium channels KCNQ2 and KCNQ3
lead to hyperexcitability disorders such as epilepsy and autism spectrum disorders. However…