The mechanisms involved in plasticity in the nervous system are thought to support cognition,
and some of these processes are affected during normal ageing. Notably, cognitive …

Excitatory synaptic transmission is altered during aging in hippocampal granule cells, and
in CA3 and CA1 pyramidal cells. These functional changes contribute to age-associated …

Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against Gram-positive
and Gram-negative pathogens. It is generally administered as an infusion over 30–60 …

Normal aging is associated with impairments in stimulus recognition. In the current investigation,
object recognition was tested in adult and aged rats with the standard spontaneous …

Although hippocampal interneurons typically do not show discrete regions of elevated firing
in an environment, such as seen in pyramidal cell place fields, they do exhibit significant …

Normal aging causes a decline in object recognition. Importantly, lesions of the perirhinal
cortex produce similar deficits and also lead to object discrimination impairments when the test …

The factors that control the spatial tuning of hippocampal neurons are incompletely understood,
and there is no generally agreed upon definition of what constitutes a “place field”. One …

Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms,
including bidirectional changes in proteins critical for neuron function. Importantly, these …

The perirhinal and lateral entorhinal cortices send prominent projections to the portion of the
hippocampal CA1 subfield closest to the subiculum, but relatively little is known regarding …

The hippocampus is thought to coordinate memory consolidation by reactivating traces from
behavioral experience when the brain is not actively processing new input. In fact, during …