User profiles for S. L. Gupton

Stephanie Gupton

Associate Professor, University of North Carolina
Verified email at email.unc.edu
Cited by 5843

The growth cone cytoskeleton in axon outgrowth and guidance

EW Dent, SL Gupton, FB Gertler - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin
and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Filopodia: the fingers that do the walking

SL Gupton, FB Gertler - Science's STKE, 2007 - science.org
Filopodia are actin-based structures composed of parallel bundles of actin filaments and
various actin-associated proteins, and they play important roles in cell-cell signaling, guidance …

[HTML][HTML] Revisiting netrin-1: one who guides (axons)

NP Boyer, SL Gupton - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular milieu …

Two distinct actin networks drive the protrusion of migrating cells

A Ponti, M Machacek, SL Gupton, CM Waterman-Storer… - Science, 2004 - science.org
Cell migration initiates by extension of the actin cytoskeleton at the leading edge. Computational
analysis of fluorescent speckle microscopy movies of migrating epithelial cells revealed …

[HTML][HTML] Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration

SL Gupton, CM Waterman-Storer - Cell, 2006 - cell.com
Cells exhibit a biphasic migration-velocity response to increasing adhesion strength, with
fast migration occurring at intermediate extracellular matrix (ECM) concentration and slow …

[BOOK][B] Highly Successful Women Administrators: The Inside Stories of How They Got There.

SL Gupton, GA Slick - 1996 - ERIC
Although an underrepresentation of women in educational administration persists, the reasons
for the disparity have changed over the past 30 years. This book presents findings of a …

Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin

SL Gupton, KL Anderson, TP Kole, RS Fischer… - The Journal of cell …, 2005 - rupress.org
The actin cytoskeleton is locally regulated for functional specializations for cell motility.
Using quantitative fluorescent speckle microscopy (qFSM) of migrating epithelial cells, we …

[BOOK][B] The instructional leadership toolbox: A handbook for improving practice

SL Gupton - 2010 - books.google.com
" I applaud Gupton's focus on the learner. This is the most important tenet for a school … In
this second edition of The Instructional Leadership Toolbox, Sandra Lee Gupton examines the …

[PDF][PDF] Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis

SL Gupton, FB Gertler - Developmental cell, 2010 - cell.com
Neurons establish their unique morphology by elaborating multiple neurites that subsequently
form axons and dendrites. Neurite initiation entails significant surface area expansion, …

mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration

SL Gupton, K Eisenmann, AS Alberts… - Journal of cell …, 2007 - journals.biologists.com
… be mediated by forward expansion of the lamella network (Gupton et al., 2005; Ponti et al., …
using Metamorph software as described previously (Gupton and Waterman-Storer, 2006b). …