User profiles for Ryan P.D. Alexander
Ryan PD AlexanderUniversity of California, San Francisco Verified email at ucsf.edu Cited by 368 |
[PDF][PDF] Paradoxical hyperexcitability from NaV1. 2 sodium channel loss in neocortical pyramidal cells
Loss-of-function variants in the gene SCN2A, which encodes the sodium channel Na V 1.2,
are strongly associated with autism spectrum disorder and intellectual disability. An …
are strongly associated with autism spectrum disorder and intellectual disability. An …
[PDF][PDF] Nanoscale mobility of the apo state and TARP stoichiometry dictate the gating behavior of alternatively spliced AMPA receptors
Neurotransmitter-gated ion channels are allosteric proteins that switch on and off in response
to agonist binding. Most studies have focused on the agonist-bound, activated channel …
to agonist binding. Most studies have focused on the agonist-bound, activated channel …
[PDF][PDF] STIM1 controls neuronal Ca2+ signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior
J Hartmann, RM Karl, RPD Alexander, H Adelsberger… - Neuron, 2014 - cell.com
In central mammalian neurons, activation of metabotropic glutamate receptor type1 (mGluR1)
evokes a complex synaptic response consisting of IP 3 receptor-dependent Ca 2+ release …
evokes a complex synaptic response consisting of IP 3 receptor-dependent Ca 2+ release …
Intrinsic plasticity of cerebellar stellate cells is mediated by NMDA receptor regulation of voltage‐gated Na+ channels
RPD Alexander, D Bowie - The Journal of Physiology, 2021 - Wiley Online Library
Key points We show that NMDA receptors (NMDARs) elicit a long‐term increase in the firing
rates of inhibitory stellate cells of the cerebellum NMDARs induce intrinsic plasticity through …
rates of inhibitory stellate cells of the cerebellum NMDARs induce intrinsic plasticity through …
Cerebellar stellate cell excitability is coordinated by shifts in the gating behavior of voltage-gated Na+ and A-type K+ channels
Neuronal excitability in the vertebrate brain is governed by the coordinated activity of both
ligand- and voltage-gated ion channels. In the cerebellum, spontaneous action potential (AP) …
ligand- and voltage-gated ion channels. In the cerebellum, spontaneous action potential (AP) …
[HTML][HTML] Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding
S Farjami, RPD Alexander, D Bowie… - PLOS Computational …, 2020 - journals.plos.org
Cerebellar stellate cells (CSCs) are spontaneously active, tonically firing (5-30 Hz), inhibitory
interneurons that synapse onto Purkinje cells. We previously analyzed the excitability …
interneurons that synapse onto Purkinje cells. We previously analyzed the excitability …
[HTML][HTML] Correlations between limbic white matter and cognitive function in temporal-lobe epilepsy, preliminary findings
RPD Alexander, L Concha, TJ Snyder… - Frontiers in aging …, 2014 - frontiersin.org
The limbic system is presumed to have a central role in cognitive performance, in particular
memory. The purpose of this study was to investigate the relationship between limbic white …
memory. The purpose of this study was to investigate the relationship between limbic white …
Modeling excitability in cerebellar stellate cells: Temporal changes in threshold, latency and frequency of firing
J Mitry, RPD Alexander, S Farjami, D Bowie… - … in Nonlinear Science …, 2020 - Elsevier
Cerebellar stellate cells are inhibitory molecular interneurons that regulate the firing properties
of Purkinje cells, the sole output of cerebellar cortex. Recent evidence suggests that …
of Purkinje cells, the sole output of cerebellar cortex. Recent evidence suggests that …
Switching in cerebellar stellate cell excitability in response to a pair of inhibitory/excitatory presynaptic inputs: a dynamical system perspective
Cerebellar stellate cells form inhibitory synapses with Purkinje cells, the sole output of the
cerebellum. Upon stimulation by a pair of varying inhibitory and fixed excitatory presynaptic …
cerebellum. Upon stimulation by a pair of varying inhibitory and fixed excitatory presynaptic …
Isolated febrile seizures are not associated with structural abnormalities of the limbic system
The nature of the relationship between childhood febrile seizures (CFSs) and temporal lobe
epilepsy (TLE) remains unknown. The purpose of this study was to perform a …
epilepsy (TLE) remains unknown. The purpose of this study was to perform a …