User profiles for Ryan P.D. Alexander

Ryan PD Alexander

University of California, San Francisco
Verified email at ucsf.edu
Cited by 368

[PDF][PDF] Paradoxical hyperexcitability from NaV1. 2 sodium channel loss in neocortical pyramidal cells

PWE Spratt, RPD Alexander, R Ben-Shalom… - Cell Reports, 2021 - cell.com
Loss-of-function variants in the gene SCN2A, which encodes the sodium channel Na V 1.2,
are strongly associated with autism spectrum disorder and intellectual disability. An …

[PDF][PDF] Nanoscale mobility of the apo state and TARP stoichiometry dictate the gating behavior of alternatively spliced AMPA receptors

…, R Venskutonytė, AM Perozzo, Y Yan, RPD Alexander… - Neuron, 2019 - cell.com
Neurotransmitter-gated ion channels are allosteric proteins that switch on and off in response
to agonist binding. Most studies have focused on the agonist-bound, activated channel …

[PDF][PDF] STIM1 controls neuronal Ca2+ signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior

J Hartmann, RM Karl, RPD Alexander, H Adelsberger… - Neuron, 2014 - cell.com
In central mammalian neurons, activation of metabotropic glutamate receptor type1 (mGluR1)
evokes a complex synaptic response consisting of IP 3 receptor-dependent Ca 2+ release …

Intrinsic plasticity of cerebellar stellate cells is mediated by NMDA receptor regulation of voltage‐gated Na+ channels

RPD Alexander, D Bowie - The Journal of Physiology, 2021 - Wiley Online Library
Key points We show that NMDA receptors (NMDARs) elicit a long‐term increase in the firing
rates of inhibitory stellate cells of the cerebellum NMDARs induce intrinsic plasticity through …

Cerebellar stellate cell excitability is coordinated by shifts in the gating behavior of voltage-gated Na+ and A-type K+ channels

RPD Alexander, J Mitry, V Sareen, A Khadra, D Bowie - Eneuro, 2019 - eneuro.org
Neuronal excitability in the vertebrate brain is governed by the coordinated activity of both
ligand- and voltage-gated ion channels. In the cerebellum, spontaneous action potential (AP) …

[HTML][HTML] Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding

S Farjami, RPD Alexander, D Bowie… - PLOS Computational …, 2020 - journals.plos.org
Cerebellar stellate cells (CSCs) are spontaneously active, tonically firing (5-30 Hz), inhibitory
interneurons that synapse onto Purkinje cells. We previously analyzed the excitability …

[HTML][HTML] Correlations between limbic white matter and cognitive function in temporal-lobe epilepsy, preliminary findings

RPD Alexander, L Concha, TJ Snyder… - Frontiers in aging …, 2014 - frontiersin.org
The limbic system is presumed to have a central role in cognitive performance, in particular
memory. The purpose of this study was to investigate the relationship between limbic white …

Modeling excitability in cerebellar stellate cells: Temporal changes in threshold, latency and frequency of firing

J Mitry, RPD Alexander, S Farjami, D Bowie… - … in Nonlinear Science …, 2020 - Elsevier
Cerebellar stellate cells are inhibitory molecular interneurons that regulate the firing properties
of Purkinje cells, the sole output of cerebellar cortex. Recent evidence suggests that …

Switching in cerebellar stellate cell excitability in response to a pair of inhibitory/excitatory presynaptic inputs: a dynamical system perspective

S Farjami, RPD Alexander, D Bowie, A Khadra - Neural Computation, 2020 - direct.mit.edu
Cerebellar stellate cells form inhibitory synapses with Purkinje cells, the sole output of the
cerebellum. Upon stimulation by a pair of varying inhibitory and fixed excitatory presynaptic …

Isolated febrile seizures are not associated with structural abnormalities of the limbic system

G Gong, RPD Alexander, F Shi, C Beaulieu, DW Gross - Epilepsy research, 2012 - Elsevier
The nature of the relationship between childhood febrile seizures (CFSs) and temporal lobe
epilepsy (TLE) remains unknown. The purpose of this study was to perform a …