Background De novo mutations in PURA have recently been described to cause PURA
syndrome, a neurodevelopmental disorder characterised by severe intellectual disability (ID), …

Damage to specific brain circuits can cause specific neuropsychiatric symptoms. Therapeutic
stimulation to these same circuits may modulate these symptoms. To determine whether …

Cerebral small vessel disease (CSVD) is considered to be caused by an increased
permeability of the blood-brain barrier and results in enlargement of Virchow Robin spaces (VRs), …

Background Whether the treatment of rhythmic and periodic electroencephalographic (EEG)
patterns in comatose survivors of cardiac arrest improves outcomes is uncertain. Methods …

Objective This nationwide cohort study evaluates seizure responses to immunotherapy and
antiepileptic drugs (AEDs) in patients with anti-leucine-rich glioma-inactivated 1 (LGI1), anti-…

Background and Purpose— Asymptomatic lacunar infarcts, white matter lesions, cerebral
microbleeds, and enlarged perivascular spaces are MRI markers of cerebral small vessel …

The blood-brain barrier (BBB) is the interface between the blood and brain tissue, which
regulates the maintenance of homeostasis within the brain. Impaired BBB integrity is …

Background and Purpose— Stroke is the leading cause of disability in the Western world;
however, few therapies are at hand to decrease this burden. Summary of Review— …

Objective Epilepsy is highly prevalent among patients with intellectual disability ( ID ), and
seizure control is often difficult. Identification of the underlying etiology in this patient group is …

Importance It remains unclear why lesions in some locations cause epilepsy while others do
not. Identifying the brain regions or networks associated with epilepsy by mapping these …