Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
antidepressant class today and exert their antidepressant-like effects by increasing synaptic …

Corticotropin-releasing factor (CRF) administered intraventricularly (0.5 nmol) was found to
increase the discharge rates of locus coeruleus (LC) neurons in anesthetized rats. A similar …

Stress is associated with the onset and severity of several psychiatric disorders that occur
more frequently in women than men, including posttraumatic stress disorder (PTSD) and …

Although hypothalamic–pituitary–adrenal axis activation is generally considered to be the
hallmark of the stress response, many of the same stimuli that initiate this response also …

Although the higher incidence of stress-related psychiatric disorders in females is well
documented, its basis is unknown. Here, we show that the receptor for corticotropin-releasing …

Anatomic and electrophysiologic studies have provided evidence that CRF meets some of
the criteria as a neurotransmitter in the noradrenergic nucleus, the locus coeruleus (LC), …

Interventions to address the US opioid crisis primarily target opioid use, misuse, and
addiction, but because the opioid crisis includes multiple substances, the opioid specificity of …

The present study examined the regional localization of corticotropin-releasing factor (CRF)-
and 5-hydroxytryptamine (5-HT)-immunoreactive (IR) fibers within the rat dorsal raphe …

Publisher Summary This chapter discusses recent studies of the noradrenergic locus coeruleus
(LC) system to consider its possible roles in emotion. It describes the recent studies of …

The present study was designed to determine the relationship between the discharge of
noradrenergic locus coeruleus (LC) neurons and norepinephrine release in the medial …