User profiles for Riccardo Melani
Riccardo MelaniNew York University School of Medicine Verified email at nyulangone.org Cited by 907 |
Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex
C Romberg, S Yang, R Melani… - Journal of …, 2013 - Soc Neuroscience
Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal
cell bodies and proximal dendrites and are involved in the control of brain plasticity and the …
cell bodies and proximal dendrites and are involved in the control of brain plasticity and the …
[HTML][HTML] Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology
Alzheimer's disease is the most prevalent tauopathy and cause of dementia. We investigate
the hypothesis that reactivation of plasticity can restore function in the presence of neuronal …
the hypothesis that reactivation of plasticity can restore function in the presence of neuronal …
Dendritic spine instability in a mouse model of CDKL5 disorder is rescued by insulin-like growth factor 1
G Della Sala, E Putignano, G Chelini, R Melani… - Biological …, 2016 - Elsevier
Background CDKL5 (cyclin-dependent kinase-like 5) is mutated in many severe
neurodevelopmental disorders, including atypical wRett syndrome. CDKL5 was shown to interact …
neurodevelopmental disorders, including atypical wRett syndrome. CDKL5 was shown to interact …
[PDF][PDF] Peri-synaptic glia recycles brain-derived neurotrophic factor for LTP stabilization and memory retention
Glial cells respond to neuronal activation and release neuroactive molecules (termed "gliotransmitters")
that can affect synaptic activity and modulate plasticity. In this study, we used …
that can affect synaptic activity and modulate plasticity. In this study, we used …
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome
Mutations in MECP2 gene have been identified in more than 95% of patients with classic
Rett syndrome, one of the most common neurodevelopmental disorders in females. Taking …
Rett syndrome, one of the most common neurodevelopmental disorders in females. Taking …
Loss of Mecp2 causes atypical synaptic and molecular plasticity of parvalbumin-expressing interneurons reflecting Rett syndrome–like sensorimotor defects
N Morello, R Schina, F Pilotto, M Phillips, R Melani… - Eneuro, 2018 - eneuro.org
Rett syndrome (RTT) is caused in most cases by loss-of-function mutations in the X-linked
gene encoding methyl CpG-binding protein 2 (MECP2). Understanding the pathological …
gene encoding methyl CpG-binding protein 2 (MECP2). Understanding the pathological …
[PDF][PDF] Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake
R Melani, NX Tritsch - Cell reports, 2022 - cell.com
Dopamine (DA)-releasing neurons in the substantia nigra pars compacta (SNc DA ) inhibit
target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) …
target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) …
p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization
D Repetto, P Camera, R Melani, N Morello… - Journal of …, 2014 - Soc Neuroscience
A major challenge in the neuroscience field is the identification of molecules and pathways
that control synaptic plasticity and memory. Dendritic spines play a pivotal role in these …
that control synaptic plasticity and memory. Dendritic spines play a pivotal role in these …
Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals
Environmental enrichment (EE) has a remarkable impact on brain development. Continuous
exposure to EE from birth determines a significant acceleration of visual system maturation …
exposure to EE from birth determines a significant acceleration of visual system maturation …
Diminished fear extinction in adolescents is associated with an altered somatostatin interneuron–mediated inhibition in the infralimbic cortex
Background Rodents and humans show an attenuation of fear extinction during adolescence,
which coincides with the onset of several psychiatric disorders. Although the ethological …
which coincides with the onset of several psychiatric disorders. Although the ethological …