User profiles for Riccardo Melani

Riccardo Melani

New York University School of Medicine
Verified email at nyulangone.org
Cited by 907

Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex

C Romberg, S Yang, R Melani… - Journal of …, 2013 - Soc Neuroscience
Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal
cell bodies and proximal dendrites and are involved in the control of brain plasticity and the …

[HTML][HTML] Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

…, TJ Bussey, BL Schneider, P Aebischer, R Melani… - Experimental …, 2015 - Elsevier
Alzheimer's disease is the most prevalent tauopathy and cause of dementia. We investigate
the hypothesis that reactivation of plasticity can restore function in the presence of neuronal …

Dendritic spine instability in a mouse model of CDKL5 disorder is rescued by insulin-like growth factor 1

G Della Sala, E Putignano, G Chelini, R Melani… - Biological …, 2016 - Elsevier
Background CDKL5 (cyclin-dependent kinase-like 5) is mutated in many severe
neurodevelopmental disorders, including atypical wRett syndrome. CDKL5 was shown to interact …

[PDF][PDF] Peri-synaptic glia recycles brain-derived neurotrophic factor for LTP stabilization and memory retention

B Vignoli, G Battistini, R Melani, R Blum, S Santi… - Neuron, 2016 - cell.com
Glial cells respond to neuronal activation and release neuroactive molecules (termed "gliotransmitters")
that can affect synaptic activity and modulate plasticity. In this study, we used …

iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome

…, C Fallerini, S Butini, S Brogi, S Furini, R Melani… - Experimental cell …, 2018 - Elsevier
Mutations in MECP2 gene have been identified in more than 95% of patients with classic
Rett syndrome, one of the most common neurodevelopmental disorders in females. Taking …

Loss of Mecp2 causes atypical synaptic and molecular plasticity of parvalbumin-expressing interneurons reflecting Rett syndrome–like sensorimotor defects

N Morello, R Schina, F Pilotto, M Phillips, R Melani… - Eneuro, 2018 - eneuro.org
Rett syndrome (RTT) is caused in most cases by loss-of-function mutations in the X-linked
gene encoding methyl CpG-binding protein 2 (MECP2). Understanding the pathological …

[PDF][PDF] Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake

R Melani, NX Tritsch - Cell reports, 2022 - cell.com
Dopamine (DA)-releasing neurons in the substantia nigra pars compacta (SNc DA ) inhibit
target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) …

p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization

D Repetto, P Camera, R Melani, N Morello… - Journal of …, 2014 - Soc Neuroscience
A major challenge in the neuroscience field is the identification of molecules and pathways
that control synaptic plasticity and memory. Dendritic spines play a pivotal role in these …

Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals

L Baroncelli, MC Cenni, R Melani, G Deidda, S Landi… - …, 2017 - Elsevier
Environmental enrichment (EE) has a remarkable impact on brain development. Continuous
exposure to EE from birth determines a significant acceleration of visual system maturation …

Diminished fear extinction in adolescents is associated with an altered somatostatin interneuron–mediated inhibition in the infralimbic cortex

P Koppensteiner, R Von Itter, R Melani, C Galvin… - Biological …, 2019 - Elsevier
Background Rodents and humans show an attenuation of fear extinction during adolescence,
which coincides with the onset of several psychiatric disorders. Although the ethological …