Astrocytes locally translate transcripts in their peripheral processes
…, AM Lake, R Khazanchi, R Ouwenga… - Proceedings of the …, 2017 - National Acad Sciences
Local translation in neuronal processes is key to the alteration of synaptic strength necessary
for long-term potentiation, learning, and memory. Here, we present evidence that regulated …
for long-term potentiation, learning, and memory. Here, we present evidence that regulated …
[PDF][PDF] MicroRNAs induce a permissive chromatin environment that enables neuronal subtype-specific reprogramming of adult human fibroblasts
Directed reprogramming of human fibroblasts into fully differentiated neurons requires massive
changes in epigenetic and transcriptional states. Induction of a chromatin environment …
changes in epigenetic and transcriptional states. Induction of a chromatin environment …
[PDF][PDF] A population-based study of autosomal-recessive disease-causing mutations in a founder population
JX Chong, R Ouwenga, RL Anderson… - The American Journal of …, 2012 - cell.com
The decreasing cost of whole-genome and whole-exome sequencing has resulted in a
renaissance for identifying Mendelian disease mutations, and for the first time it is possible to …
renaissance for identifying Mendelian disease mutations, and for the first time it is possible to …
Transcriptomic analysis of ribosome-bound mRNA in cortical neurites in vivo
Localized translation in neurites helps regulate synaptic strength and development. Dysregulation
of local translation is associated with many neurological disorders. However, due to …
of local translation is associated with many neurological disorders. However, due to …
Mammary tumors induce select cognitive impairments
LM Pyter, SF Cochrane, RL Ouwenga, PN Patel… - Brain, behavior, and …, 2010 - Elsevier
Cancer, in addition to many other chronic diseases, is associated with serious and problematic
behavioral symptoms, including cognitive impairments. In humans, various factors likely …
behavioral symptoms, including cognitive impairments. In humans, various factors likely …
[HTML][HTML] Fmrp targets or not: long, highly brain-expressed genes tend to be implicated in autism and brain disorders
RL Ouwenga, J Dougherty - Molecular autism, 2015 - Springer
Background Many studies have demonstrated a robust statistical overlap between genes
whose transcripts are reported as Fragile X Mental Retardation Protein (Fmrp)-binding targets …
whose transcripts are reported as Fragile X Mental Retardation Protein (Fmrp)-binding targets …
The differences in local translatome across distinct neuron types is mediated by both baseline cellular differences and post-transcriptional mechanisms
Local translation in neurites is a phenomenon that enhances the spatial segregation of proteins
and their functions away from the cell body, yet it is unclear how local translation varies …
and their functions away from the cell body, yet it is unclear how local translation varies …
Disclosure of genetic research results to members of a founder population
RL Anderson, K Murray, JX Chong, R Ouwenga… - Journal of genetic …, 2014 - Springer
There is currently extensive discussion and debate in the literature on how, when, and to
whom genetic research results should be returned (see Genetics in Medicine, April 2012 issue)…
whom genetic research results should be returned (see Genetics in Medicine, April 2012 issue)…
Regulation of Local Translation in Neuronal Processes of Specific Cell Types
R Ouwenga - 2018 - openscholarship.wustl.edu
Local translation in distal processes of the neuron was discovered over 35 years ago, but
only with the recent advancements in microscopy, molecular techniques, and high throughput …
only with the recent advancements in microscopy, molecular techniques, and high throughput …
Peripheral tumors induce depressive-like behaviors and cytokine production and alter hypothalamic-pituitary-adrenal axis regulation
LM Pyter, V Pineros, JA Galang… - Proceedings of the …, 2009 - National Acad Sciences
A strong and positive correlation exists between chronic disease and affective disorders, but
the biological mechanisms underlying this relationship are not known. Here we show that …
the biological mechanisms underlying this relationship are not known. Here we show that …