Rationale: Cardiac fibrosis plays a critical role in the pathogenesis of heart failure. Excessive
accumulation of extracellular matrix (ECM) resulting from cardiac fibrosis impairs cardiac …

In cortical neurons, pore-forming α-subunits of the Kv4 subfamily underlie the fast transient
outward K + current (I A ). Considerable evidence has accumulated demonstrating specific …

Key points • The cytosolic K + channel accessory subunit, K + channel interacting protein 2 (KChIP2),
was previously suggested to be critical in the generation of cardiac fast transient …

The Kv channel interacting proteins (KChIPs) were identified in a yeast two hybrid screen
using the N terminus of Kv4.3 as bait. Previous studies have demonstrated that KChIP2 …

Considerable evidence suggests that day–night rhythms in the functional expression of
subthreshold potassium (K + ) channels regulate daily oscillations in the spontaneous firing rates …

Native myocardial voltage-gated sodium (Na V) channels function in macromolecular
complexes comprising a pore-forming (α) subunit and multiple accessory proteins. Here, we …

Voltage-gated sodium (Na V ) channels are responsible for the initiation and propagation of
action potentials. In the heart, the predominant Na V 1.5 α subunit is composed of four …

Rapidly activating and inactivating A-type K + currents (I A ) encoded by Kv4.2 and Kv4.3
pore-forming (α) subunits of the Kv4 subfamily are key regulators of neuronal excitability. …

Neurons in the suprachiasmatic nucleus (SCN) generate circadian changes in the rates of
spontaneous action potential firing that regulate and synchronize daily rhythms in physiology …

Familial hypertrophic cardiomyopathy (HCM), linked to mutations in myosin, myosin-binding
proteins and other sarcolemmal proteins, is associated with increased risk of life threatening …