The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding glutamate …

Receptors for N-methyl-D-aspartate (NMDA) are involved in many plastic and pathological
processes in the brain. Glycine has been reported to potentiate NMDA responses in neurons …

The neurotransmitter glutamate mediates excitatory synaptic transmission throughout the
brain. A family of genes encoding subunits of the non-N-methyl-D-aspartate (non-NMDA) type …

Objective The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to develop
in rats, suggesting that altered gene expression is involved. The KD typically is used in …

1. The CA1 region of rat hippocampal slices bathed in 8.5 mM interstitial K+ ([K+]o) exhibited
spontaneous 20- to 90-s electrographic seizures at regular intervals of 1–8 min. In these …

One compelling challenge in the therapy of epilepsy is to develop anti-epileptogenic drugs
with an impact on the disease progression. The search for novel targets has focused recently …

Many genes whose expression is restricted to neurons in the brain contain a silencer
element (RE1/NRSE) that limits transcription in nonneuronal cells by binding the transcription …

The rodent pilocarpine model of epilepsy exhibits hippocampal sclerosis and spontaneous
seizures and thus resembles human temporal lobe epilepsy. Use of the many available …

The generalized seizures of status epilepticus (SE) trigger a series of molecular and cellular
events that produce cognitive deficits and can culminate in the development of epilepsy. …

The GluR2 subunit controls three key features of ion flux through the AMPA subtype of
glutamate receptors—calcium permeability, inward rectification, and channel block by external …