[PDF][PDF] P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury

TC Yin, JK Britt, H De Jesús-Cortés, Y Lu, RM Genova… - Cell reports, 2014 - cell.com
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block
neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules …

Acute axonal degeneration drives development of cognitive, motor, and visual deficits after blast-mediated traumatic brain injury in mice

TC Yin, JR Voorhees, RM Genova, KC Davis… - Eneuro, 2016 - eneuro.org
Axonal degeneration is a prominent feature of many forms of neurodegeneration, and also
an early event in blast-mediated traumatic brain injury (TBI), the signature injury of soldiers in …

Glucocorticoid and androgen signaling pathways diverge between advertisement calling and non-calling fish

RM Genova, MA Marchaterre, R Knapp, D Fergus… - Hormones and …, 2012 - Elsevier
Behavioral and neuroendocrine mechanisms of social vocalization in teleost fish are influenced
by the glucocorticoid cortisol and the androgen 11-ketotestosterone (11kT). The relative …

Manipulation of BK channel expression is sufficient to alter auditory hair cell thresholds in larval zebrafish

KN Rohmann, JA Tripp, RM Genova… - Journal of …, 2014 - journals.biologists.com
Non-mammalian vertebrates rely on electrical resonance for frequency tuning in auditory
hair cells. A key component of the resonance exhibited by these cells is an outward calcium-…

[HTML][HTML] Neprilysin inhibition promotes corneal wound healing

RM Genova, KJ Meyer, MG Anderson, MM Harper… - Scientific reports, 2018 - nature.com
Neprilysin (NEP), an ectoenzyme that modulates inflammation by degrading neuropeptides,
was recently identified in the human corneal epithelium. The cornea expresses many NEP …

The role of neprilysin in ocular surface homeostasis and corneal wound healing

RM Genova - 2020 - search.proquest.com
The cornea is a transparent, dome-shaped structure that transmits and refracts light, and
serves as a physical barrier against ocular pathogens. As the outermost tissue of the eye, the …

Linking Symptom Inventories using Semantic Textual Similarity

…, RM Edelstein, C Esopenko, HM Genova… - arXiv preprint arXiv …, 2023 - arxiv.org
An extensive library of symptom inventories has been developed over time to measure clinical
symptoms, but this variety has led to several long standing issues. Most notably, results …

The role of neutral endopeptidase in ocular surface homeostasis and corneal wound healing

R Genova, A Pieper, M Harper - Investigative Ophthalmology & …, 2018 - iovs.arvojournals.org
Purpose: Neutral endopeptidase (NEP) modulates inflammation by metabolizing signaling
peptides. Recently NEP was identified in the human cornea, a tissue that expresses many of …

[HTML][HTML] A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E

…, KA Brayton, SK Wilson, BM Di Genova… - International Journal for …, 2020 - Elsevier
New treatments for the diseases caused by apicomplexans are needed. Recently, we
determined that tartrolon E (trtE), a secondary metabolite derived from a shipworm symbiotic …

[HTML][HTML] A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment

…, RJ Taugher, T Vogel, CC Cychosz, R Genova… - PLoS …, 2021 - journals.plos.org
Primary cilia are microtubule-based organelles present on most cells that regulate many
physiological processes, ranging from maintaining energy homeostasis to renal function. …