[HTML][HTML] Shared and distinct transcriptomic cell types across neocortical areas

…, KE Hirokawa, K Lathia, C Rimorin, M Tieu, R Larsen… - Nature, 2018 - nature.com
The neocortex contains a multitude of cell types that are segregated into layers and functionally
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …

[HTML][HTML] Morphological diversity of single neurons in molecularly defined cell types

…, G Hong, L Huang, S Kebede, HC Kuo, R Larsen… - Nature, 2021 - nature.com
Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types 1 , 2 , yet our knowledge of its diversity remains limited. Here, to …

[PDF][PDF] A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality

…, RS Larsen, MM Takeno, L Huang, H Gu, R Larsen… - Cell, 2018 - cell.com
Modern genetic approaches are powerful in providing access to diverse cell types in the brain
and facilitating the study of their function. Here, we report a large set of driver and reporter …

Local connectivity and synaptic dynamics in mouse and human neocortex

…, A Mukora, D Sandman, G Williams, R Larsen… - Science, 2022 - science.org
We present a unique, extensive, and open synaptic physiology analysis platform and dataset.
Through its application, we reveal principles that relate cell type to synaptic properties and …

A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex

…, N Keller, U Knoblich, JD Larkin, R Larsen… - Nature …, 2020 - nature.com
To understand how the brain processes sensory information to guide behavior, we must know
how stimulus representations are transformed throughout the visual cortex. Here we report …

Aberrant cortical activity in multiple GCaMP6-expressing transgenic mouse lines

…, JD Larkin, K Roll, S Cross, TV Nguyen, R Larsen… - eneuro, 2017 - eneuro.org
Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique,
care must be taken to ensure that the tool itself does not unduly affect the system under study. …

[PDF][PDF] Enhancer viruses for combinatorial cell-subclass-specific labeling

…, TK Kim, T Zhou, M Mortrud, S Yao, R Larsen… - Neuron, 2021 - cell.com
Rapid cell type identification by new genomic single-cell analysis methods has not been met
with efficient experimental access to these cell types. To facilitate access to specific neural …

Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types

…, G Hong, L Huang, S Kebede, HC Kuo, R Larsen… - BioRxiv, 2019 - biorxiv.org
Ever since the seminal findings of Ramon y Cajal, dendritic and axonal morphology has
been recognized as a defining feature of neuronal types. Yet our knowledge concerning the …

A large-scale, standardized physiological survey reveals higher order coding throughout the mouse visual cortex

…, S Jewell, N Keller, U Knoblich, J Larkin, R Larsen… - BioRxiv, 2018 - biorxiv.org
To understand how the brain processes sensory information to guide behavior, we must know
how stimulus representations are transformed throughout the visual cortex. Here we report …

A multimodal cell census and atlas of the mammalian primary motor cortex

…, M Kroll, X Kuang, HC Kuo, BB Lake, R Larsen… - Biorxiv, 2020 - biorxiv.org
We report the generation of a multimodal cell census and atlas of the mammalian primary
motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (…