Cortical DNA methylation maintains remote memory

CA Miller, CF Gavin, JA White, RR Parrish… - Nature …, 2010 - nature.com
A behavioral memory's lifetime represents multiple molecular lifetimes, suggesting the
necessity for a self-perpetuating signal. One candidate is DNA methylation, a transcriptional …

Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the …

RR Parrish, AJ Albertson, SC Buckingham, JJ Hablitz… - Neuroscience, 2013 - Elsevier
Status epilepticus (SE) triggers abnormal expression of genes in the hippocampus, such as
glutamate receptor subunit epsilon-2 (Grin2b/Nr2b) and brain-derived neurotrophic factor (…

Epigenetic mechanisms: critical contributors to long-term memory formation

FD Lubin, S Gupta, RR Parrish… - The …, 2011 - journals.sagepub.com
Recent advances in chromatin biology have identified a role for epigenetic mechanisms in
the regulation of neuronal gene expression changes, a necessary process for proper synaptic …

Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus

…, A Calin, NK Codadu, R Wright, SE Newey, RR Parrish… - Brain, 2019 - academic.oup.com
Status epilepticus is defined as a state of unrelenting seizure activity. Generalized convulsive
status epilepticus is associated with a rapidly rising mortality rate, and thus constitutes a …

Indirect effects of halorhodopsin activation: potassium redistribution, nonspecific inhibition, and spreading depolarization

RR Parrish, CMKG Scott, T Jackson-Taylor… - Journal of …, 2023 - Soc Neuroscience
The movement of ions in and out of neurons can exert significant effects on neighboring
cells. Here we report several experimentally important consequences of activation of the …

Direct bisulfite sequencing for examination of DNA methylation with gene and nucleotide resolution from brain tissues

RR Parrish, JJ Day, FD Lubin - Current Protocols in …, 2012 - Wiley Online Library
DNA methylation is an epigenetic modification that is essential for the development and
mature function of the central nervous system. Due to the relevance of this modification to the …

Multiscale recordings reveal the dynamic spatial structure of human seizures

…, T Eissa, E Merricks, B Gill, RR Parrish… - Neurobiology of …, 2019 - Elsevier
The cellular activity underlying human focal seizures, and its relationship to key signatures in
the EEG recordings used for therapeutic purposes, has not been well characterized despite …

Feedforward inhibition ahead of ictal wavefronts is provided by both parvalbumin‐and somatostatin‐expressing interneurons

RR Parrish, NK Codadu… - The Journal of …, 2019 - Wiley Online Library
Key points There is a rapid interneuronal response to focal activity in cortex, which restrains
laterally propagating activity, including spreading epileptiform activity. The interneuronal …

Methionine increases BDNF DNA methylation and improves memory in epilepsy

RR Parrish, SC Buckingham, KL Mascia… - Annals of clinical …, 2015 - Wiley Online Library
Objective Temporal lobe epilepsy ( TLE ) patients exhibit signs of memory impairments even
when seizures are pharmacologically controlled. Surprisingly, the underlying molecular …

Optogenetic stimulation reveals a latent tipping point in cortical networks during ictogenesis

RT Graham, RR Parrish, L Alberio, EL Johnson… - Brain, 2023 - academic.oup.com
Brain-state transitions are readily apparent from changes in brain rhythms, 1 but are difficult
to predict, suggestive that the underlying cause is latent to passive recording methods. …