User profiles for R. Cools

Roshan Cools

Professor of Cognitive Neuropsychiatry, Radboud University Nijmegen
Verified email at donders.ru.nl
Cited by 23757

Inverted-U–shaped dopamine actions on human working memory and cognitive control

R Cools, M D'Esposito - Biological psychiatry, 2011 - Elsevier
Brain dopamine (DA) has long been implicated in cognitive control processes, including
working memory. However, the precise role of DA in cognition is not well-understood, partly …

Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease

R Cools - Neuroscience & Biobehavioral Reviews, 2006 - Elsevier
It is well recognised that patients with Parkinson's disease exhibit cognitive deficits, even in
the earliest disease stages. Whereas, l-DOPA therapy in early Parkinson's disease is …

The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning

L Clark, R Cools, TW Robbins - Brain and cognition, 2004 - Elsevier
Converging evidence from human lesion, animal lesion, and human functional neuroimaging
studies implicates overlapping neural circuitry in ventral prefrontal cortex in decision-…

Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands

R Cools, RA Barker, BJ Sahakian… - Cerebral cortex, 2001 - academic.oup.com
We investigated how dopamine (DA) systems contribute to cognitive performance in the
domain of learning and attentional flexibility by examining effects of withdrawing DA-ergic …

Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging

R Cools, L Clark, AM Owen… - Journal of …, 2002 - Soc Neuroscience
Event-related functional magnetic resonance imaging was used to measure blood oxygenation
level-dependent responses in 13 young healthy human volunteers during performance …

L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease

R Cools, RA Barker, BJ Sahakian, TW Robbins - Neuropsychologia, 2003 - Elsevier
In the current study we investigated the role of dopamine in attentional and socio-emotional
functioning by examining effects of withdrawing dopaminergic medication in patients with …

Serotoninergic regulation of emotional and behavioural control processes

R Cools, AC Roberts, TW Robbins - Trends in cognitive sciences, 2008 - cell.com
5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of emotional,
cognitive and behavioural control processes. However, its precise contribution is still not …

[HTML][HTML] Mechanisms of motivation–cognition interaction: challenges and opportunities

…, MM Botvinick, CS Carver, R Cools, R Custers… - Cognitive, affective, & …, 2014 - Springer
Recent years have seen a rejuvenation of interest in studies of motivation–cognition interactions
arising from many different areas of psychology and neuroscience. The present issue of …

Mechanisms of cognitive set flexibility in Parkinson's disease

R Cools, RA Barker, BJ Sahakian, TW Robbins - Brain, 2001 - academic.oup.com
Cools AR. Role of the neostriatal dopaminergic activity in sequencing and selecting
behavioural strategies: facilitation of processes involved in selecting the best strategy in a stressful …

Dopaminergic modulation of high‐level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET

R Cools, E Stefanova, RA Barker, TW Robbins… - Brain, 2002 - academic.oup.com
This study examined the effects of l‐dopa medication in patients with Parkinson’s disease on
cortical and subcortical blood flow changes during two tasks known to involve frontostriatal …