User profiles for R. J. Seeley

Randy Seeley

HK Ransom Professor of Surgery, University of Michigan
Verified email at med.umich.edu
Cited by 62684

Central nervous system control of food intake

MW Schwartz, SC Woods, D Porte Jr, RJ Seeley… - Nature, 2000 - nature.com
New information regarding neuronal circuits that control food intake and their hormonal
regulation has extended our understanding of energy homeostasis, the process whereby energy …

Signals that regulate food intake and energy homeostasis

SC Woods, RJ Seeley, D Porte Jr, MW Schwartz - Science, 1998 - science.org
Feeding behavior is critical for survival. In addition to providing all of the body's macronutrients
(carbohydrates, lipids, and proteins) and most micronutrients (minerals and vitamins), …

[HTML][HTML] Glucagon-like peptide 1 (GLP-1)

…, F Reimann, DA Sandoval, TW Schwartz, RJ Seeley… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-…

Identification of targets of leptin action in rat hypothalamus.

MW Schwartz, RJ Seeley, LA Campfield… - The Journal of …, 1996 - Am Soc Clin Investig
… food intake not only under ad libitum feeding conditions, but also potently inhibits the
hyperphagic response elicited by fasting, leading to a delayed recovery of lost weight (Seeley, RJ, …

Hypothalamic mTOR signaling regulates food intake

…, SC Kozma, G Thomas, SC Woods, RJ Seeley - Science, 2006 - science.org
The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that
regulates cell-cycle progression and growth by sensing changes in energy status. We …

[HTML][HTML] A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy …

BJ Brehm, RJ Seeley, SR Daniels… - The Journal of Clinical …, 2003 - academic.oup.com
Untested alternative weight loss diets, such as very low carbohydrate diets, have unsubstantiated
efficacy and the potential to adversely affect cardiovascular risk factors. Therefore, we …

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

…, DE Prunkard, D Porte Jr, SC Woods, RJ Seeley… - Diabetes, 1996 - Am Diabetes Assoc
Correction of the obese state induced by genetic leptin deficiency reduces elevated levels
of both blood glucose and hypothalamic neuropeptide Y (NPY) mRNA in ob/ob mice. To …

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus

MW Schwartz, RJ Seeley, SC Woods, DS Weigle… - Diabetes, 1997 - Am Diabetes Assoc
Melanocortins are peptides, cleaved from the pro-opiomelanocortin (POMC) precursor, that
act in the brain to reduce food intake and are potential mediators of leptin action. In the …

Obesity and leptin resistance: distinguishing cause from effect

MG Myers, RL Leibel, RJ Seeley… - Trends in Endocrinology & …, 2010 - cell.com
Because leptin reduces food intake and body weight, the coexistence of elevated leptin
levels with obesity is widely interpreted as evidence of ‘leptin resistance.' Indeed, obesity …

FXR is a molecular target for the effects of vertical sleeve gastrectomy

…, DA Sandoval, R Kohli, F Bäckhed, RJ Seeley - Nature, 2014 - nature.com
Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are at present the
most effective therapy for the treatment of obesity, and are associated with considerable …