User profiles for Qiudong Deng
 | Qiudong DengEmory University Verified email at emory.edu Cited by 2081 |
[HTML][HTML] A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer's disease
Here, we report proteomic analyses of 129 human cortical tissues to define changes associated
with the asymptomatic and symptomatic stages of Alzheimer's disease (AD). Network …
with the asymptomatic and symptomatic stages of Alzheimer's disease (AD). Network …
FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage
Abnormal cytoplasmic accumulation of Fused in Sarcoma (FUS) in neurons defines subtypes
of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). FUS …
of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). FUS …
Intracellular proteolysis of progranulin generates stable, lysosomal granulins that are haploinsufficient in patients with frontotemporal dementia caused by GRN …
Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN),
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively. …
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively. …
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells
Progranulin (PGRN) is a secreted glycoprotein expressed in neurons and glia that is
implicated in neuronal survival on the basis that mutations in the GRN gene causing …
implicated in neuronal survival on the basis that mutations in the GRN gene causing …
[HTML][HTML] Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal …
Background Progranulin (PGRN) is a secreted growth factor important for neuronal survival
and may do so, in part, by regulating lysosome homeostasis. Mutations in the PGRN gene (…
and may do so, in part, by regulating lysosome homeostasis. Mutations in the PGRN gene (…
[HTML][HTML] Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by …
Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin (PGRN)
are a common cause of frontotemporal dementia (FTD). Homozygous GRN …
are a common cause of frontotemporal dementia (FTD). Homozygous GRN …
Changes in the detergent‐insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression
Despite a key role of amyloid‐beta (Aβ) in Alzheimer's disease (AD), mechanisms that link
Aβ plaques to tau neurofibrillary tangles and cognitive decline still remain poorly understood. …
Aβ plaques to tau neurofibrillary tangles and cognitive decline still remain poorly understood. …
ON direction‐selective ganglion cells in the mouse retina
Two types of ganglion cells (RGCs) compute motion direction in the retina: the ON–OFF
direction‐selective ganglion cells (DSGCs) and the ON DSGCs. The ON DSGCs are much less …
direction‐selective ganglion cells (DSGCs) and the ON DSGCs. The ON DSGCs are much less …
[HTML][HTML] Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
C Verbeeck, Q Deng, M DeJesus-Hernandez… - Molecular …, 2012 - Springer
Background Mutations in the gene encoding the RNA-binding protein fused in sarcoma (FUS)
can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely …
can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely …
Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory
…, R Revilla-Sanchez, IM Quadros, Q Deng… - Journal of …, 2014 - Soc Neuroscience
Cognitive dysfunction is a common symptom in many neuropsychiatric disorders and directly
correlates with poor patient outcomes. The majority of prolonged inhibitory signaling in the …
correlates with poor patient outcomes. The majority of prolonged inhibitory signaling in the …