User profiles for Qingchun Tong

Qingchun Tong

University of Texas at Houston
Verified email at uth.tmc.edu
Cited by 5665

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

Q Tong, CP Ye, JE Jones, JK Elmquist… - Nature neuroscience, 2008 - nature.com
The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits
is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) …

[HTML][HTML] Paraventricular hypothalamus mediates diurnal rhythm of metabolism

…, BR Arenkiel, K Eckel-Mahan, Y Xu, Q Tong - Nature …, 2020 - nature.com
Defective rhythmic metabolism is associated with high-fat high-caloric diet (HFD) feeding,
ageing and obesity; however, the neural basis underlying HFD effects on diurnal metabolism …

[HTML][HTML] An obligate role of oxytocin neurons in diet induced energy expenditure

…, AK Sutton, R Zhao, BB Lowell, DP Olson, Q Tong - 2012 - journals.plos.org
Oxytocin neurons represent one of the major subsets of neurons in the paraventricular
hypothalamus (PVH), a critical brain region for energy homeostasis. Despite substantial evidence …

[PDF][PDF] VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch

Y Liu, OA Samad, L Zhang, B Duan, Q Tong, C Lopes… - Neuron, 2010 - cell.com
Itch can be suppressed by painful stimuli, but the underlying neural basis is unknown. We
generated conditional null mice in which vesicular glutamate transporter type 2 (VGLUT2)-…

Profound and redundant functions of arcuate neurons in obesity development

…, Y Xu, M Xue, BR Arenkiel, Q Wu, G Shu, Q Tong - Nature …, 2020 - nature.com
The current obesity epidemic faces a lack of mechanistic insights. It is known that the acute
activity changes of a growing number of brain neurons rapidly alter feeding behaviour; …

A cholinergic basal forebrain feeding circuit modulates appetite suppression

…, B Tepe, JC Carlson, K Ung, J Selever, Q Tong… - Nature, 2016 - nature.com
Atypical food intake is a primary cause of obesity and other eating and metabolic disorders.
Insight into the neural control of feeding has previously focused mainly on signalling …

[PDF][PDF] Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia

Q Tong, CP Ye, RJ McCrimmon, H Dhillon, B Choi… - Cell metabolism, 2007 - cell.com
The importance of neuropeptides in the hypothalamus has been experimentally established.
Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters …

[HTML][HTML] GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure

D Kong, Q Tong, C Ye, S Koda, PM Fuller, MJ Krashes… - Cell, 2012 - cell.com
Neural regulation of energy expenditure is incompletely understood. By genetically disrupting
GABAergic transmission in a cell-specific fashion, and by combining this with selective …

[PDF][PDF] Glucose stimulation of hypothalamic MCH neurons involves KATP channels, is modulated by UCP2, and regulates peripheral glucose homeostasis

D Kong, L Vong, LE Parton, C Ye, Q Tong, X Hu… - Cell metabolism, 2010 - cell.com
Blood glucose levels are tightly controlled, a process thought to be orchestrated primarily by
peripheral mechanisms (insulin secretion by β cells, and insulin action on muscle, fat, and …

A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease

…, Y Zhao, W Cao, H Zheng, H Xu, Q Tong… - Science translational …, 2022 - science.org
Triggering receptor expressed on myeloid cells 2 (TREM2) plays crucial roles in Alzheimer’s
disease (AD) by regulating microglia migration toward, and phagocytosis of oligomeric …