The epileptic encephalopathies are conditions in which neurological deterioration is
attributable entirely or partly to epileptic activity and is due to very frequent or severe seizures or …

Objective: We investigated whether interictal epileptiform discharges (IED) in the human
hippocampus are related to impairment of specific memory processes, and which characteristics …

Place cells are hippocampal neurons whose discharge is strongly related to a rat's location
in its environment. The existence of place cells has led to the proposal that they are part of an …

Objective Cognitive impairment is common in epilepsy, particularly in memory function.
Interictal spikes (IISs) are thought to disrupt cognition, but it is difficult to delineate their …

Hippocampus place cell discharge is an important model system for understanding cognition,
but evidence is missing that the place code is under the kind of dynamic attentional control …

Dravet syndrome (DS) is a childhood disorder associated with loss-of-function mutations in
SCN1A and is characterized by frequent seizures and severe cognitive impairment. Animal …

Epilepsy is often associated with cognitive and behavioral impairments that can have profound
impact on the quality of life of patients. Although the mechanisms of cognitive impairment …

In the hippocampus, pyramidal cells encode information in two major ways: rate coding and
temporal coding. Rate coding, in which information is coded through firing frequency, is …

Humans can recognize and navigate in a room when its contents have been rearranged. Rats
also adapt rapidly to movements of objects in a familiar environment. We therefore set out …

Cognitive impairment is a common comorbidity in pediatric epilepsy that can severely affect
quality of life. In many cases, antiepileptic treatments fail to improve cognition. Therefore, a …