User profiles for Philip Washbourne
Philip WashbourneAssociate Professor of Biology, University of Oregon Verified email at uoregon.edu Cited by 3666 |
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis
Axon outgrowth during development and neurotransmitter release depends on exocytotic
mechanisms, although what protein machinery is common to or differentiates these processes …
mechanisms, although what protein machinery is common to or differentiates these processes …
Rapid recruitment of NMDA receptor transport packets to nascent synapses
P Washbourne, JE Bennett, AK McAllister - Nature neuroscience, 2002 - nature.com
Although many of the molecules involved in synaptogenesis have been identified, the
sequence and kinetics of synapse assembly in the central nervous system (CNS) remain largely …
sequence and kinetics of synapse assembly in the central nervous system (CNS) remain largely …
Cell adhesion molecules in synapse formation
Neuronal transmission relies on signals transmitted through a vast array of excitatory and
inhibitory neuronal synaptic connections. How do axons communicate with dendrites to build …
inhibitory neuronal synaptic connections. How do axons communicate with dendrites to build …
Techniques for gene transfer into neurons
P Washbourne, AK McAllister - Current opinion in neurobiology, 2002 - Elsevier
To illuminate the function of the thousands of genes that make up the complexity of the
nervous system, it is critical to be able to introduce and express DNA in neurons. Over the past …
nervous system, it is critical to be able to introduce and express DNA in neurons. Over the past …
Cycling of NMDA receptors during trafficking in neurons before synapse formation
P Washbourne, XB Liu, EG Jones… - Journal of …, 2004 - Soc Neuroscience
The trafficking of glutamate receptors in neurons is of the utmost importance for synapse
formation and synaptic plasticity. Recently, we demonstrated that both NMDA and AMPA …
formation and synaptic plasticity. Recently, we demonstrated that both NMDA and AMPA …
[HTML][HTML] Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis
…, F El-Sabeawy, AK McAllister, P Washbourne - Neural …, 2009 - Springer
Background The cell adhesion molecule pair neuroligin1 (Nlg1) and β-neurexin (β-NRX) is
a powerful inducer of postsynaptic differentiation of glutamatergic synapses in vitro. Because …
a powerful inducer of postsynaptic differentiation of glutamatergic synapses in vitro. Because …
Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors
Z Fu, P Washbourne, P Ortinski… - Journal of …, 2003 - journals.physiology.org
The discovery that neuroligin is a key protein involved in synapse formation offers the
unprecedented opportunity to induce functional synapses between neurons and heterologous cells…
unprecedented opportunity to induce functional synapses between neurons and heterologous cells…
[PDF][PDF] Forebrain control of behaviorally driven social orienting in zebrafish
…, D Ncube, A Tallafuss, JS Eisen, P Washbourne - Current biology, 2018 - cell.com
Deficits in social engagement are diagnostic of multiple neurodevelopmental disorders,
including autism and schizophrenia [1]. Genetically tractable animal models like zebrafish (…
including autism and schizophrenia [1]. Genetically tractable animal models like zebrafish (…
Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish
…, Y Li, S Seredick, J Eisen, P Washbourne - …, 2012 - journals.biologists.com
To understand the molecular mechanisms of development it is essential to be able to turn
genes on and off at will and in a spatially restricted fashion. Morpholino oligonucleotides (MOs…
genes on and off at will and in a spatially restricted fashion. Morpholino oligonucleotides (MOs…
Glutamate drives the touch response through a rostral loop in the spinal cord of zebrafish embryos
…, J Ryan, L Saint‐Amant, P Washbourne - Developmental …, 2009 - Wiley Online Library
Characterizing connectivity in the spinal cord of zebrafish embryos is not only prerequisite
to understanding the development of locomotion, but is also necessary for maximizing the …
to understanding the development of locomotion, but is also necessary for maximizing the …