VEGF is an essential retrograde trophic factor for motoneurons

PM Calvo, RG Hernández… - Proceedings of the …, 2022 - National Acad Sciences
VEGF was initially discovered due to its angiogenic activity and therefore named “vascular
endothelial growth factor.” However, its more recently discovered neurotrophic activity may be …

Functional diversity of motoneurons in the oculomotor system

R G. Hernández, PM Calvo, R Blumer… - Proceedings of the …, 2019 - National Acad Sciences
Extraocular muscles contain two types of muscle fibers according to their innervation pattern:
singly innervated muscle fibers (SIFs), similar to most skeletal muscle fibers, and multiply …

VEGF and neuronal survival

PM Calvo, RG Hernández, AM Pastor… - The …, 2024 - journals.sagepub.com
Vascular endothelial growth factor (VEGF) is well known for its angiogenic activity, but
recent evidence has revealed a neuroprotective action of this factor on injured or diseased …

Synaptic loss and firing alterations in Axotomized Motoneurons are restored by vascular endothelial growth factor (VEGF) and VEGF-B

PM Calvo, RR de la Cruz, AM Pastor - Experimental Neurology, 2018 - Elsevier
Vascular endothelial growth factor (VEGF), also known as VEGF-A, was discovered due to its
vasculogenic and angiogenic activity, but a neuroprotective role for VEGF was later proven …

[HTML][HTML] Role of vascular endothelial growth factor as a critical neurotrophic factor for the survival and physiology of motoneurons

PM Calvo, RG Hernández, RR de la Cruz… - Neural Regeneration …, 2023 - journals.lww.com
Vascular endothelial growth factor (VEGF) was discovered by its angiogenic activity. However,
during evolution, it appeared earlier as a neurotrophic factor required for the development …

[HTML][HTML] Vascular endothelial growth factor: an essential neurotrophic factor for motoneurons?

PM Calvo, AM Pastor… - Neural Regeneration …, 2018 - journals.lww.com
Vascular endothelial growth factor (VEGF), an angiogenic factor with neuroprotective effects:
The VEGF was initially characterized by its vasculogenic and angiogenic activities and its …

[HTML][HTML] Eye movements but not vision drive the development of palisade endings

G Carrero-Rojas, PM Calvo, T Lischka… - … & Visual Science, 2022 - tvst.arvojournals.org
Purpose: To test whether visual experience and/or eye movements drive the postnatal
development of palisade endings in extraocular muscles. Methods: In three newborn cats, the …

[HTML][HTML] Palisade endings have an exocytotic machinery but lack acetylcholine receptors and distinct acetylcholinesterase activity

…, G Carrero-Rojas, PM Calvo… - … & Visual Science, 2020 - iovs.arvojournals.org
Purpose: The purpose of this work was to test whether palisade endings express structural
and molecular features of exocytotic machinery, and are associated with acetylcholine …

Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF

PM Calvo, RR de la Cruz, AM Pastor… - Brain Structure and …, 2023 - Springer
The potassium chloride cotransporter 2 (KCC2) is the main Cl − extruder in neurons. Any
alteration in KCC2 levels leads to changes in Cl − homeostasis and, consequently, in the …

Proprioceptors in extraocular muscles

R Blumer, G Carrero‐Rojas, PM Calvo… - Experimental …, 2024 - Wiley Online Library
Proprioception is the sense that lets us perceive the location, movement and action of the
body parts. The proprioceptive apparatus includes specialized sense organs (proprioceptors) …