User profiles for Paul A. Dutchak

Paul Dutchak

Université Laval
Verified email at ulaval.ca
Cited by 2939

[HTML][HTML] Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones

PA Dutchak, T Katafuchi, AL Bookout, JH Choi, TY Ruth… - Cell, 2012 - cell.com
Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects
carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible, fed-state …

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

W Wei, PA Dutchak, X Wang, X Ding… - Proceedings of the …, 2012 - National Acad Sciences
The endocrine hormone fibroblast growth factor 21 (FGF21) is a powerful modulator of glucose
and lipid metabolism and a promising drug for type 2 diabetes. Here we identify FGF21 …

[HTML][HTML] Synaptic dysfunction in ALS and FTD: Anatomical and molecular changes provide insights into mechanisms of disease

PA Gelon, PA Dutchak, CF Sephton - Frontiers in Molecular …, 2022 - frontiersin.org
Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of the …

[HTML][HTML] Metabolic networks influencing skeletal muscle fiber composition

…, CF Sephton, PA Dutchak - Frontiers in cell and …, 2018 - frontiersin.org
Advancements in metabolomic and genomic research tools are revealing new insights into
how metabolic networks can influence skeletal muscle fiber composition. In this mini-review, …

[PDF][PDF] Loss of a negative regulator of mTORC1 induces aerobic glycolysis and altered fiber composition in skeletal muscle

PA Dutchak, SJ Estill-Terpack, AA Plec, X Zhao… - Cell reports, 2018 - cell.com
The conserved GATOR1 complex consisting of NPRL2-NPRL3-DEPDC5 inhibits mammalian
target of rapamycin complex 1 (mTORC1) in response to amino acid insufficiency. Here, …

[HTML][HTML] FUS contributes to mTOR-dependent inhibition of translation

…, JP Venkatasubramani, JB Hui, PA Dutchak… - Journal of Biological …, 2020 - ASBMB
The amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)–linked RNA-binding
protein called FUS (fused in sarcoma) has been implicated in several aspects of RNA …

[PDF][PDF] Regulation of hematopoiesis and methionine homeostasis by mTORC1 inhibitor NPRL2

PA Dutchak, S Laxman, SJ Estill, C Wang, Y Wang… - Cell reports, 2015 - cell.com
Nitrogen permease regulator-like 2 (NPRL2) is a component of a conserved complex that
inhibits mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to amino acid …

[HTML][HTML] A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics

…, JC Van Swieten, D Campion, PA Dutchak… - Acta neuropathologica …, 2022 - Springer
Frontotemporal dementia (FTD) is a heterogeneous clinical disorder characterized by progressive
abnormalities in behavior, executive functions, personality, language and/or motricity. …

[HTML][HTML] Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition

…, A Rodgers, D Phaneuf, S Pozzi, PA Dutchak… - Acta Neuropathologica …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are related
neurodegenerative diseases that belong to a common disease spectrum based on overlapping …

NPRL2 inhibition of mTORC1 controls sodium channel expression and brain amino acid homeostasis

…, M Chahine, CD Proulx, CF Sephton, PA Dutchak - Eneuro, 2022 - eneuro.org
Genetic mutations in nitrogen permease regulator-like 2 (NPRL2) are associated with a wide
spectrum of familial focal epilepsies, autism, and sudden unexpected death of epileptics (…