User profiles for Patrick Lansdon

Patrick Lansdon

University of Kansas
Verified email at ku.edu
Cited by 80

Milk-whey diet substantially suppresses seizure-like phenotypes of paraShu, a Drosophila voltage-gated sodium channel mutant

J Kasuya, A Iyengar, HL Chen, P Lansdon… - Journal of …, 2019 - Taylor & Francis
The Drosophila mutant para Shu harbors a dominant, gain-of-function allele of the voltage-gated
sodium channel gene, paralytic (para). The mutant flies display severe seizure-like …

[HTML][HTML] Wild-type Caenorhabditis elegans isolates exhibit distinct gene expression profiles in response to microbial infection

P Lansdon, M Carlson, BD Ackley - BMC genomics, 2022 - Springer
The soil-dwelling nematode Caenorhabditis elegans serves as a model system to study innate
immunity against microbial pathogens. C. elegans have been collected from around the …

Lithium-responsive seizure-like hyperexcitability is caused by a mutation in the Drosophila voltage-gated sodium channel gene paralytic

GA Kaas, J Kasuya, P Lansdon, A Ueda, A Iyengar… - eneuro, 2016 - eneuro.org
Shudderer (Shu) is an X-linked dominant mutation in Drosophila melanogaster identified
more than 40 years ago. A previous study showed that Shu caused spontaneous tremors and …

[HTML][HTML] The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen

S Benomar, P Lansdon, AM Bender… - PLoS …, 2020 - journals.plos.org
Caenorhabditis elegans are soil-dwelling nematodes and models for understanding innate
immunity and infection. Previously, we developed a novel fluorescent dye (KR35) that …

[HTML][HTML] Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy

E Petruccelli, P Lansdon, T Kitamoto - PLoS One, 2015 - journals.plos.org
Despite an established link between epilepsy and sleep behavior, it remains unclear how
specific epileptogenic mutations affect sleep and subsequently influence seizure susceptibility. …

The MAB-5/Hox family transcription factor is important for C. elegans Innate Immune Response to S. epidermidis Infection

…, EA Lundquist, BD Ackley, P Lansdon - G3: Genes, Genomes …, 2024 - academic.oup.com
Innate immunity functions as a rapid defense against broad classes of pathogenic agents.
While the mechanisms of innate immunity in response to antigen exposure are well-studied, …

Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels

HL Chen, J Kasuya, P Lansdon, G Kaas… - G3: Genes …, 2020 - academic.oup.com
Voltage-gated sodium (Na v ) channels play a central role in the generation and propagation
of action potentials in excitable cells such as neurons and muscles. To determine how the …

Abstract 2159 The MAB-5/Hox Family Transcription Factor is Important for C. elegans Innate Immune Response to S. epidermidis Infection

P Lansdon, C Kywe, E Lundquist, B Ackley - Journal of Biological Chemistry, 2024 - ASBMB
Innate immunity functions as a rapid defense against broad classes of pathogenic agents.
While the mechanisms of innate immunity in response to antigen exposure are well-studied, …

Draft Genome Sequence of Novel Staphylococcus epidermidis Strain EVL2000, Exhibiting Pathogenicity against Caenorhabditis elegans

N Do, BD Ackley, P Lansdon - Microbiology Resource …, 2022 - Am Soc Microbiol
Staphylococcus epidermidis is a frequent cause of nosocomial infections occurring after the
insertion of indwelling medical devices. Here, we report the 2.5-Mb draft genome of S. …

A comparative analysis of Caenorhabditis and Drosophila transcriptional changes in response to pathogen infection

RL Unckless, PA Lansdon, BD Ackley - bioRxiv, 2020 - biorxiv.org
Drosophila melanogaster and Caenorhabditis elegans are well-used invertebrate models for
studying the innate immune system. The organisms are susceptible to bacterial pathogens …