User profiles for Patrick Lansdon
Patrick LansdonUniversity of Kansas Verified email at ku.edu Cited by 80 |
Milk-whey diet substantially suppresses seizure-like phenotypes of paraShu, a Drosophila voltage-gated sodium channel mutant
The Drosophila mutant para Shu harbors a dominant, gain-of-function allele of the voltage-gated
sodium channel gene, paralytic (para). The mutant flies display severe seizure-like …
sodium channel gene, paralytic (para). The mutant flies display severe seizure-like …
[HTML][HTML] Wild-type Caenorhabditis elegans isolates exhibit distinct gene expression profiles in response to microbial infection
The soil-dwelling nematode Caenorhabditis elegans serves as a model system to study innate
immunity against microbial pathogens. C. elegans have been collected from around the …
immunity against microbial pathogens. C. elegans have been collected from around the …
Lithium-responsive seizure-like hyperexcitability is caused by a mutation in the Drosophila voltage-gated sodium channel gene paralytic
Shudderer (Shu) is an X-linked dominant mutation in Drosophila melanogaster identified
more than 40 years ago. A previous study showed that Shu caused spontaneous tremors and …
more than 40 years ago. A previous study showed that Shu caused spontaneous tremors and …
[HTML][HTML] The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen
Caenorhabditis elegans are soil-dwelling nematodes and models for understanding innate
immunity and infection. Previously, we developed a novel fluorescent dye (KR35) that …
immunity and infection. Previously, we developed a novel fluorescent dye (KR35) that …
[HTML][HTML] Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy
E Petruccelli, P Lansdon, T Kitamoto - PLoS One, 2015 - journals.plos.org
Despite an established link between epilepsy and sleep behavior, it remains unclear how
specific epileptogenic mutations affect sleep and subsequently influence seizure susceptibility. …
specific epileptogenic mutations affect sleep and subsequently influence seizure susceptibility. …
The MAB-5/Hox family transcription factor is important for C. elegans Innate Immune Response to S. epidermidis Infection
Innate immunity functions as a rapid defense against broad classes of pathogenic agents.
While the mechanisms of innate immunity in response to antigen exposure are well-studied, …
While the mechanisms of innate immunity in response to antigen exposure are well-studied, …
Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels
Voltage-gated sodium (Na v ) channels play a central role in the generation and propagation
of action potentials in excitable cells such as neurons and muscles. To determine how the …
of action potentials in excitable cells such as neurons and muscles. To determine how the …
Abstract 2159 The MAB-5/Hox Family Transcription Factor is Important for C. elegans Innate Immune Response to S. epidermidis Infection
Innate immunity functions as a rapid defense against broad classes of pathogenic agents.
While the mechanisms of innate immunity in response to antigen exposure are well-studied, …
While the mechanisms of innate immunity in response to antigen exposure are well-studied, …
Draft Genome Sequence of Novel Staphylococcus epidermidis Strain EVL2000, Exhibiting Pathogenicity against Caenorhabditis elegans
Staphylococcus epidermidis is a frequent cause of nosocomial infections occurring after the
insertion of indwelling medical devices. Here, we report the 2.5-Mb draft genome of S. …
insertion of indwelling medical devices. Here, we report the 2.5-Mb draft genome of S. …
A comparative analysis of Caenorhabditis and Drosophila transcriptional changes in response to pathogen infection
Drosophila melanogaster and Caenorhabditis elegans are well-used invertebrate models for
studying the innate immune system. The organisms are susceptible to bacterial pathogens …
studying the innate immune system. The organisms are susceptible to bacterial pathogens …