DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic silencing
of cancer-related genes. Since the relationship between aberrant DNA methylation and …

Introduction: Schizophrenia, a devastating disorder with onset in adolescence or young
adulthood, afflicts 1% of the population leading to severe social, educational, and occupational …

Mechanosensory hair cells release glutamate at ribbon synapses to excite postsynaptic
afferent neurons, via AMPA-type ionotropic glutamate receptors (AMPARs). However, type II …

Asymmetric localization of adenomatous polyposis coli (APC) to the ends of a subset of
microtubules located in the leading edges is essential for the establishment of front-rear polarity …

Acoustic information propagates from the ear to the brain via spiral ganglion neurons that
innervate hair cells in the cochlea. These afferents include unmyelinated type II fibers that …

Type II spiral ganglion neurons (SGNs) are small caliber, unmyelinated afferents that extend
dendritic arbors hundreds of microns along the cochlear spiral, contacting many outer hair …

The cochlea is innervated by type I and type II afferent neurons. Type I afferents are myelinated,
larger diameter neurons that send a single dendrite to contact a single inner hair cell, …

Glutamatergic receptor expression is mostly unknown in adults with fragile X syndrome (FXS).
Favorable behavioral effects of negative allosteric modulators (NAMs) of the metabotropic …

Until postnatal day (P) 12, inner hair cells of the rat cochlea are invested with both afferent
and efferent synaptic connections. With the onset of hearing at P12, the efferent synapses …

Par polarity complex, consisting of Par3, Par6, and aPKC, plays a conserved role in the
establishment and maintenance of polarization in diverse cellular contexts. Recent reports …